Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein

PloS One
D T BradleyAnne E Hughes

Abstract

Neisseria meningitidis can cause severe infection in humans. Polymorphism of Complement Factor H (CFH) is associated with altered risk of invasive meningococcal disease (IMD). We aimed to find whether polymorphism of other complement genes altered risk and whether variation of N. meningitidis factor H binding protein (fHBP) affected the risk association. We undertook a case-control study with 309 European cases and 5,200 1958 Birth Cohort and National Blood Service cohort controls. We used additive model logistic regression, accepting P<0.05 as significant after correction for multiple testing. The effects of fHBP subfamily on the age at infection and severity of disease was tested using the independent samples median test and Student's T test. The effect of CFH polymorphism on the N. meningitidis fHBP subfamily was investigated by logistic regression and Chi squared test. Rs12085435 A in C8B was associated with odds ratio (OR) of IMD (0.35 [95% CI 0.19-0.67]; P = 0.03 after correction). A CFH haplotype tagged by rs3753396 G was associated with IMD (OR 0.56 [95% CI 0.42-0.76], P = 1.6x10⁻⁴). There was no bacterial load (CtrA cycle threshold) difference associated with carriage of this haplotype. Host CFH haplotype and meningoco...Continue Reading

References

Jan 25, 2002·Archives of Disease in Childhood·S J HackettC A Hart
Mar 19, 2003·The Journal of Experimental Medicine·Vega MasignaniMariagrazia Pizza
Jul 19, 2003·Science·Linda JohanssonAnn-Beth Jonsson
Mar 25, 2004·Infection and Immunity·Leah D FletcherGary W Zlotnick
Mar 12, 2005·Science·Jonathan L HainesMargaret A Pericak-Vance
Mar 12, 2005·Science·Robert J KleinJosephine Hoh
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
May 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gregory S HagemanRando Allikmets
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanna JarvaSeppo Meri
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guillermo MadicoSanjay Ram
Jul 11, 2006·Ophthalmology·Eric A PostelMargaret A Pericak-Vance
Sep 19, 2008·Journal of Cellular and Molecular Medicine·Maciej M MarkiewskiJohn D Lambris
Nov 28, 2008·The Lancet Infectious Diseases·Matthijs C BrouwerDiederik van de Beek
Dec 17, 2008·Forensic Science International. Genetics·C PhillipsUNKNOWN SNPforID Consortium
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tom DartonRobert C Read
Apr 24, 2009·Vaccine·Francesco Tedesco
Jul 4, 2009·Microbiology·Peter T Beernink, Dan M Granoff
Jul 21, 2009·Immunology Letters·Peter F Zipfel
Sep 5, 2009·Nature Reviews. Immunology·Peter F Zipfel, Christine Skerka
Mar 26, 2010·The Lancet Infectious Diseases·Matthijs C BrouwerDiederik van de Beek
Aug 10, 2010·Nature Genetics·Sonia DavilaUNKNOWN International Meningococcal Genetics Consortium
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay RamPeter A Rice
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa A LewisSanjay Ram
Feb 16, 2013·Expert Review of Anti-infective Therapy·Adam P Dale, Robert C Read
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Roman PrymulaPeter M Dull

❮ Previous
Next ❯

Citations

Nov 3, 2016·Scientific Reports·Federico Martinón-TorresUNKNOWN EUCLIDS consortium members - Imperial College London (www.euclids-project.eu)
May 11, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ewelina GowinDanuta Januszkiewicz-Lewandowska
Aug 3, 2019·Brain : a Journal of Neurology·Diederik L H KoelmanDiederik van de Beek
Nov 20, 2016·Frontiers in Immunology·Eckhard R Podack, George P Munson
Dec 31, 2019·Journal of Neuroinflammation·E Soemirien KasanmoentalibDiederik van de Beek
Feb 19, 2020·Human Genetics·Stephanie HodeibVanessa Sancho-Shimizu
Aug 21, 2019·Frontiers in Immunology·Karita Haapasalo, Seppo Meri

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
chip

Software Mentioned

SPSS
Excel
PLINK
R
TYPER

Related Concepts

Related Feeds

Bacterial Protein Structures

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.