Susceptibility-weighted imaging and diffusion-weighted imaging findings in central nervous system monomorphic B cell post-transplant lymphoproliferative disorder before and after treatment and comparison with primary B cell central nervous system lymphoma

Journal of Neuro-oncology
Daniel Thomas GinatPeter Pytel

Abstract

The purpose of this article is to review the MRI features of monomorphic central nervous system post-transplant lymphoproliferative disorder (CNS PTLD), including diffusion-weighted and susceptibility-weighted sequences before and after treatment and to compare the imaging findings with those of primary central nervous system B cell lymphoma (PCNS BCL). Retrospective review of the brain MRI characteristics in patients with pathology proven monomorphic CNS PTLD and PCNS BCL was performed. In particular, the enhancement, diffusion-weighted, susceptibility-weighted MRI characteristics of the lesions were evaluated. In addition, the diffusion-weighted, susceptibility-weighted MRI features after treatment for CNS PTLD were evaluated. A total of 12 lesions in six patients with CNS PTLD and 12 lesions in nine patients with PCNS BCL were identified on MRI. Among the CNS PTLD lesions with post-contrast images, 80 % demonstrated peripheral enhancement. All of the CNS PTLD lesions contained foci of intratumoral susceptibility signal (ITSS) and the average mean ADC values and ratios were 0.892 × 10(-3) mm(2)/s (standard deviation: 0.082 × 10(-3) mm(2)/s) and 1.19 (standard deviation: 0.15), respectively. On the other hand, 75 % of the PCNS...Continue Reading

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Citations

Nov 29, 2011·Journal of the Neurological Sciences·Itay LotanIsrael Steiner
Jun 14, 2019·Journal of Neuro-oncology·Leon D KaulenJoachim M Baehring
Dec 14, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Eman MarieReza Vali
Apr 30, 2020·AJR. American Journal of Roentgenology·Matthew L WhiteTimothy C Greiner
May 14, 2020·Journal of Pediatric Hematology/oncology·Trevor StoneMilad Yazdani

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