Suspect Screening and Regulatory Databases: A Powerful Combination To Identify Emerging Micropollutants

Environmental Science & Technology
Pablo Gago-FerreroLutz Ahrens

Abstract

This study demonstrates that regulatory databases combined with the latest advances in high resolution mass spectrometry (HRMS) can be efficiently used to prioritize and identify new, potentially hazardous pollutants being discharged into the aquatic environment. Of the approximately 23000 chemicals registered in the database of the National Swedish Product Register, 160 potential organic micropollutants were prioritized through quantitative knowledge of market availability, quantity used, extent of use on the market, and predicted compartment-specific environmental exposure during usage. Advanced liquid chromatography (LC)-HRMS-based suspect screening strategies were used to search for the selected compounds in 24 h composite samples collected from the effluent of three major wastewater treatment plants (WWTPs) in Sweden. In total, 36 tentative identifications were successfully achieved, mostly for substances not previously considered by environmental scientists. Of these substances, 23 were further confirmed with reference standards, showing the efficiency of combining a systematic prioritization strategy based on a regulatory database and a suspect-screening approach. These findings show that close collaboration between scie...Continue Reading

References

Nov 25, 2000·Biochimica Et Biophysica Acta·M J Scott, M N Jones
Jan 12, 2002·Journal of Environmental Monitoring : JEM·E Fries, W Puttmann
Mar 26, 2004·Regulatory Toxicology and Pharmacology : RTP·Hans SandersonKeith R Solomon
Feb 4, 2010·Environmental Science & Technology·Pablo A Lara-MartínEduardo González-Mazo
Feb 19, 2010·Environmental Science & Technology·Philip H Howard, Derek C G Muir
Mar 27, 2010·Arhiv za higijenu rada i toksikologiju·Tomislav Ivanković, Jasna Hrenović
Jul 14, 2010·Journal of Mass Spectrometry : JMS·Hisayuki HoraiTakaaki Nishioka
Aug 31, 2010·Environmental Science & Technology·Damian E HelblingKathrin Fenner
Sep 2, 2010·Environmental Science & Technology·Pablo A Lara-MartínBruce J Brownawell
Jul 12, 2011·Environmental Science & Technology·Philip H Howard, Derek C G Muir
Dec 23, 2011·Chemosphere·Rosario RodilDarío Prada-Rodríguez
Nov 21, 2012·Environmental Toxicology and Chemistry·Xiao-Ying Qv, Jian-Guo Jiang
Feb 21, 2013·Environmental Pollution·Rosa María Baena-NoguerasPablo A Lara-Martín
Jan 31, 2014·Environmental Science & Technology·Emma L SchymanskiJuliane Hollender
Mar 14, 2014·Environmental Science & Technology·Sebastian HuntschaJuliane Hollender
Mar 19, 2014·Environmental Pollution·Rosa María Baena-NoguerasPablo A Lara-Martín
May 14, 2014·Environmental Science & Technology·Christoph MoschetJuliane Hollender
Sep 11, 2014·Journal of Hazardous Materials·Félix HernándezFrancisco J López
Sep 27, 2014·Analytical and Bioanalytical Chemistry·Aurea C Chiaia-HernandezJuliane Hollender
May 16, 2015·Analytical and Bioanalytical Chemistry·Emma L SchymanskiJuliane Hollender
Sep 30, 2015·Environmental Science & Technology·Pablo Gago-FerreroNikolaos S Thomaidis

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Citations

Jun 21, 2019·Water Environment Research : a Research Publication of the Water Environment Federation·Yankui TangXiang Sun
Jul 2, 2019·International Journal of Phytoremediation·Melanie L Hedgespeth, Elizabeth Guthrie Nichols
Feb 8, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Janis RuskoVadims Bartkevics
Mar 16, 2021·Environmental Science & Technology·Steven KutarnaHui Peng
Apr 30, 2021·Analytical Methods : Advancing Methods and Applications·B González-GayaO Zuloaga
Sep 16, 2020·The Science of the Total Environment·Aurea C Chiaia-HernándezJuliane Hollender
Mar 29, 2019·The Science of the Total Environment·Meaghan E GuyaderChristopher P Higgins
Oct 17, 2020·Environmental Science & Technology·Shiru WangTeng Zeng
Dec 12, 2019·Analytical Chemistry·Susan D Richardson, Susana Y Kimura

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