Suspect Screening Using LC-QqTOF Is a Useful Tool for Detecting Drugs in Biological Samples

Journal of Analytical Toxicology
Jennifer M ColbyKara L Lynch

Abstract

High-resolution mass spectrometers (HRMS), including quadrupole time of flight mass analyzers (QqTOF), are becoming more prevalent as screening tools in clinical and forensic toxicology laboratories. Among other advantages, HRMS instruments can collect untargeted, full-scan mass spectra. These datasets can be analyzed retrospectively using a combination of techniques, which can extend the drug detection capabilities. Most laboratories using HRMS in production settings perform untargeted data collection, but analyze data in a targeted manner. To perform targeted analysis, a laboratory must first analyze a reference standard to determine the expected characteristics of a given compound. In an alternate technique known as suspect screening, compounds can be tentatively identified without the use of reference standards. Instead, predicted and/or intrinsic characteristics of a compound, such as the accurate mass, isotope pattern, and product ion spectrum are used to determine its presence in a sample. The fact that reference standards are not required a priori makes this data analysis approach very attractive, especially for the ever-changing landscape of novel psychoactive substances. In this work, we compared the performance of fo...Continue Reading

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Citations

Apr 2, 2019·Critical Reviews in Clinical Laboratory Sciences·Xander M R Van WijkJennifer M Colby
Nov 22, 2018·Journal of Analytical Toxicology·Xander M R van WijkKara L Lynch
Feb 13, 2020·Mass Spectrometry Reviews·Scott A BordenPierangela Palma
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Jun 28, 2020·Journal of Analytical Toxicology·Jon B StephensonJessica M Mehan
Sep 19, 2019·The Clinical Biochemist. Reviews·Darren R Allen, Brett C McWhinney
Jan 7, 2019·Analytical and Bioanalytical Chemistry·Jon R SobusElin M Ulrich
Nov 29, 2020·Analytical and Bioanalytical Chemistry·Hans H Maurer
Jan 2, 2021·Forensic Science International : Synergy·Wing-Sum ChanBobbie Kwok-Keung Cheung

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