Suspected anaphylactoid reaction following intravenous administration of a gadolinium-based contrast agent in three dogs undergoing magnetic resonance imaging

Veterinary Anaesthesia and Analgesia
Nicolas M Girard, Elizabeth A Leece

Abstract

Anaphylactoid reactions were suspected in three dogs following the intravenous administration of the contrast agent gadobenate dimeglumine 0.05 mmol kg(-1) (Multihance). Case 1: A 14 kg 6-year-old atopic female dog was anaesthetized for brain magnetic resonance imaging (MRI). All monitored parameters remained stable during the procedure. Fifteen minutes following MR completion; facial, peri-orbital and sublingual oedema were noted. Resolution of the oedema was rapid and uneventful following treatment of clinical signs over 2 hours. Case 2: A 16 kg 10-month-old male dog was anaesthetized for brain and neck MRI. Ten minutes after MR contrast intravenous (IV) injection; heart rate (HR) increased (85-120 beats minute(-1)), mean arterial blood pressure (MAP) decreased (from 70 to 43 mmHg) and PE'CO(2) decreased (from 4.66 to 3.19 kPa). Labial, periorbital and lingual oedema were noted. Clinical signs responded to fluid bolus administration. The dog vomited in recovery but oedema resolved within one hour. Case 3: A 34 kg 2-year-old atopic male dog was anaesthetized for head MRI. Within 5 minutes of MR contrast IV injection; the dog suffered severe cardiovascular collapse. MRI procedure was aborted and administration of anaesthetics d...Continue Reading

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Citations

Sep 5, 2012·Equine Veterinary Journal·G Manso-DíazO Taeymans
Jul 17, 2013·Journal of Veterinary Emergency and Critical Care·Daniella L Shmuel, Yonaira Cortes
Jul 20, 2010·Veterinary Anaesthesia and Analgesia·Elizabeth Armitage-Chan
Jul 20, 2010·Veterinary Anaesthesia and Analgesia·Alastair R MairMiguel Martinez
Jun 20, 2014·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Alyce L MarksKatherine H Deanna
Dec 23, 2014·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Arnaud Louvet, Anne-Carole Duconseille
Sep 24, 2020·The Journal of Veterinary Medical Science·Haruka TamogiKazuto Yamashita
Mar 23, 2021·Journal of Veterinary Emergency and Critical Care·Megan E HelgesonKate R Kierski

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