Suspected chronic myocarditis at cardiac MR: diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence

Radiology
Matthias GutberletUwe Kühl

Abstract

To retrospectively compare the diagnostic accuracy of three cardiac magnetic resonance (MR) imaging approaches for the detection of histologic and immunohistologic criteria (reference standard) proved myocardial inflammation in patients clinically suspected of having chronic myocarditis (CMC). Cardiac MR imaging was performed in 83 consecutive patients (55 male, 28 female; mean age, 44.8 years +/- 17.7 [standard deviation]) clinically suspected of having CMC, after written informed consent was obtained according to guidelines of the local ethics committee, which approved the study. T2-weighted triple-inversion-recovery imaging to calculate the edema ratio (ER), T1-weighted imaging before and after contrast agent administration to calculate the myocardial global relative enhancement (gRE), and inversion-recovery gradient-echo imaging to evaluate areas of late gadolinium enhancement (LE) were performed. The MR results were correlated with the endomyocardial biopsy (EMB) findings to detect intramyocardial inflammation and cardiotropic viral genomes analyzed at polymerase chain reaction assay. For statistical analyses, receiver operating characteristic analysis and the Wilcoxon test for unpaired data were used because the Kolomogor...Continue Reading

References

Feb 1, 1994·Circulation Research·T A MartinoM J Sole
Nov 9, 2000·The New England Journal of Medicine·A M Feldman, D McNamara
Nov 13, 2001·The American Journal of Cardiology·K P ThelemanW C Roberts
Jul 9, 2002·Journal of Molecular and Cellular Cardiology·Jay W Mason
Dec 10, 2002·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·O RiekerM Thelen
Jan 4, 2003·Radiology·Patrick M BossuytUNKNOWN Standards for Reporting of Diagnostic Accuracy
Aug 20, 2003·Circulation·Uwe KühlReinhard Kandolf
Oct 16, 2003·International Journal of Cardiology·Michel NoutsiasHeinz-Peter Schultheiss
Mar 25, 2004·Expert Review of Cardiovascular Therapy·Michel NoutsiasUwe Kühl
Jun 7, 2005·Journal of the American College of Cardiology·Hassan Abdel-AtyJeanette Schulz-Menger
Sep 21, 2005·Circulation·Uwe KühlHeinz-Peter Schultheiss

❮ Previous
Next ❯

Citations

Dec 22, 2009·Herz·Michel NoutsiasBernhard Maisch
Aug 3, 2010·European Radiology·Thoralf NiendorfJeanette Schulz-Menger
Jul 26, 2011·European Radiology·Tomasz Miszalski-JamkaJacek Musiał
Sep 17, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael JeserichAnnette Geibel
Mar 2, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Matthias Gutberlet, Holger Thiele
May 29, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael JeserichAnnette Geibel
Oct 26, 2010·The International Journal of Cardiovascular Imaging·Arthur E StillmanUNKNOWN European Society of Cardiac Radiology
Feb 25, 2011·The International Journal of Cardiovascular Imaging·Knut Haakon StensaethNils Einar Klow
Jan 29, 2011·Cardiology in the Young·Lindsay J MayDeborah S Fruitman
Apr 10, 2009·The New England Journal of Medicine·Leslie T Cooper
Jul 12, 2008·European Heart Journal·Robert DennertStephane Heymans
Mar 15, 2011·European Heart Journal·Juerg Schwitter, Andrew E Arai
Jul 5, 2013·European Heart Journal·Alida L P CaforioUNKNOWN European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
Dec 19, 2008·Cardiology in Review·Katarina H NelsonLuis Afonso
Jan 11, 2013·Influenza Research and Treatment·Akira UkimuraYumiko Kanzaki
May 19, 2010·Circulation·UNKNOWN American College of Cardiology Foundation Task Force on Expert Consensus DocumentsPamela K Woodard
Aug 28, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Huedayi KorkusuzThomas J Vogl
Jul 9, 2009·Drugs·Uwe Kühl, Heinz-Peter Schultheiss
Jun 28, 2011·AJR. American Journal of Roentgenology·Edward T D HoeySanjiv Sharma
May 5, 2011·Case Reports in Medicine·Edouard GerbaudPierre Coste
Apr 30, 2013·Annals of Pediatric Cardiology·Efrén Martínez-QuintanaPaula Junquera-Rionda
Apr 5, 2014·Cardiology in Review·Roman PanovskyVladimir Kincl
Jun 14, 2014·European Heart Journal Cardiovascular Imaging·Emmanuelle VermesMatthias G Friedrich
May 5, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M A G M OlimulderC von Birgelen
Jan 23, 2014·The International Journal of Cardiovascular Imaging·Matteo PerfettiGiovanni Donato Aquaro
Jan 21, 2010·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M A G M OlimulderM A Galjee
Jun 10, 2014·Radiology·Julian A LuetkensClaas P Naehle
Oct 24, 2014·Radiology·Albert de Roos, Charles B Higgins
Oct 21, 2011·Radiology·Karen G Ordovas, Charles B Higgins
Nov 15, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jadranka StojanovskaGisela C Mueller
Feb 14, 2013·The International Journal of Cardiovascular Imaging·Gavin C W ChuMatthias G Friedrich
Apr 29, 2010·Current Cardiology Reports·Myra Cocker, Matthias G Friedrich
Nov 2, 2012·Heart Failure Reviews·Alida L P CaforioS Iliceto
Jan 23, 2013·Der Radiologe·M D'AnastasiD Theisen
Jan 23, 2013·Der Radiologe·M GutberletL Lehmkuhl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.