PMID: 9179819May 1, 1997Paper

Suspected mitochondrial myopathy in a Jack Russell terrier

The Journal of Small Animal Practice
N J OlbyJ E Houlton

Abstract

A Jack Russell terrier with a history of progressive exercise intolerance was examined at the age of four months and again 10 months later. Clinical examination revealed a stunted, thin dog with a stilted gait. The dog had raised lactate levels before and after feeding and a raised lactate/pyruvate ratio after feeding, indicating a metabolic abnormality. Histochemical evaluation of muscle biopsies revealed subsarcolemmal accumulation of oxidative activity when stained with nicotinamide adenine dinucleotide tetrazollum reductase and ragged red fibres when stained with modified Gomori trichrome; all fibre types were involved. Ultrastructural examination of the muscle confirmed the presence of subsarcolemmal accumulations of mitochondria. Histochemical staining for the activity of enzymes of the Krebs cycle, oxidative phosphorylation and other metabolic cytosolic enzymes failed to demonstrate an abnormality. In view of the clinical picture and the biochemical and histological findings, a tentative diagnosis of mitochondrial myopathy was made. The difficulties associated with diagnosing mitochondrial disorders are discussed.

References

Oct 6, 1979·The Veterinary Record·E Herrtage, J E Houlton
Jan 1, 1992·Journal of Inherited Metabolic Disease·A MunnichJ Bardet
Jan 1, 1989·Trends in Genetics : TIG·D C Wallace
Jul 1, 1986·Veterinary Pathology·R E McKerrell, K G Braund
Jan 1, 1972·Veterinary Pathology·G A SplitterC A Rawlings
Jan 1, 1974·Zentralblatt für Veterinärmedizin. Reihe A·G H WentinkH J Hendriks
Sep 1, 1981·Veterinary Pathology·K G BraundV K Ganjam
Mar 1, 1980·Veterinary Pathology·K G BraundJ R August
Mar 1, 1980·The Veterinary Record·T L LawrenceJ C Whitney
Mar 1, 1980·The Veterinary Record·J E Houlton, M E Herrtage
Jul 1, 1980·Veterinary Pathology·K G BraundP F Rumph
Dec 1, 1994·Comparative Biochemistry and Physiology. Part A, Physiology·C VijayasarathyN G Avadhani
Sep 1, 1972·Veterinary Pathology·G H WentinkH J Hendriks

❮ Previous
Next ❯

Citations

Mar 26, 1999·The Journal of Small Animal Practice·S R PlattG D Shelton
Nov 7, 2006·The Veterinary Journal·Adrian C SewellUrs Giger
Nov 11, 2006·Molecular Genetics and Metabolism·Jessie M CameronBrian H Robinson
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·Simon R Platt
Oct 12, 2004·The Veterinary Clinics of North America. Small Animal Practice·Simon R Platt, Laurent S Garosi
Oct 12, 2004·The Veterinary Clinics of North America. Small Animal Practice·G Diane Shelton
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·Peter J Dickinson, Richard A LeCouteur
Feb 19, 2000·The Veterinary Clinics of North America. Small Animal Practice·S M Taylor
Jul 28, 2016·Topics in Companion Animal Medicine·Francesca Miranda Di Mauro, Gretchen Lee Schoeffler
Sep 2, 2003·Veterinary Pathology·O PacielloS Papparella
Mar 14, 2018·Journal of Veterinary Emergency and Critical Care·Patricia G RosensteinDez Hughes
Apr 14, 2004·American Journal of Veterinary Research·Joseph J WakshlagS Dimauro
Jan 6, 2009·Journal of the American Animal Hospital Association·Susan M TaylorG Diane Shelton
Sep 30, 2008·The Veterinary Record·A TauroI P Boydell
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·G Diane Shelton, Eva Engvall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Veterinary Record
J E Houlton, M E Herrtage
The Journal of Small Animal Practice
Simon R PlattG D Shelton
The Veterinary Record
I R Griffiths, I D Duncan
© 2021 Meta ULC. All rights reserved