Suspected neurological toxicity after oral application of fluralaner (Bravecto®) in a Kooikerhondje dog

BMC Veterinary Research
Daniela GaensJoachim Geyer

Abstract

Although the new isoxazoline drug fluralaner (Bravecto®) is generally well tolerated in dogs, adverse drug reactions involving neurological dysfunction occurred in individual dogs. However, most of these cases are documented inadequately and none of them is reported and discussed in the literature. As isoxazoline drugs target neuronal chloride channels with a clear preference for invertebrates, they are considered to have a good safety profile. However, pharmacodynamic effects in the nervous system of vertebrates cannot be ruled out completely. A seven-month-old female Kooikerhondje dog was treated with Bravecto® at the recommended dose. About 24 h after administration, the dog exhibited signs of neurological toxicity, including generalized ataxia, myoclonic jerks, tremor of head and body, muscle twitching and oral dysphagia. All symptoms were transient and the dog fully recovered without any treatment after 10 h. This case report describes transient occurrence of neurological dysfunction after administration of Bravecto®. It may help to better classify adverse drug reactions after application of isoxazoline drugs and documents a good prognosis even after occurrence of severe neurological dysfunction in the present case.

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Citations

Jun 3, 2020·Veterinary Medicine and Science·Valerie PalmieriJon P Kimball
May 28, 2020·Journal of the American Veterinary Medical Association·Xueying ZhouWalter H Hsu
Sep 17, 2020·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Rita de Cássia da Silva Machado NevesAna Maria Reis Ferreira
Oct 27, 2020·Frontiers in Veterinary Science·Joe S SmithMatthew T Brewer
Dec 5, 2019·BMJ Global Health·Hannah R MeredithLaith Yakob

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Methods Mentioned

BETA
X-ray
genotyping

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