Suspected Plasmodium falciparum resistance to artesunate in Cameroon: A case report.

Tropical Doctor
Elie NkwabongYvette Nkene Mawamba

Abstract

Malaria in pregnancy is associated with adverse maternal and perinatal outcomes. The first-line treatment for severe malaria in the second and third trimesters of pregnancy is parenteral artesunate, according to WHO recommendations. Resistance of Plasmodium falciparum to artesunate has not yet been noted in our country. We report a case highly suspicious of such. A pregnant woman presented with the clinical signs of malaria. After paraclinical confirmation of the diagnosis, she was admitted and injectable artesunate was given for 72 h at the recommended dosage, with antipyretic without any improvement. Artesunate was therefore replaced by parenteral quinine, with favourable evolution. Resistance of Plasmodium falciparum to artesunate might be present in our country. This patient provides a warning about possible artesunate resistance, and this calls for careful monitoring of other cases of malaria been treated with this drug to ascertain the possibility of resistant cases.

References

Feb 18, 2016·The Journal of Infection·David G LallooUNKNOWN PHE Advisory Committee on Malaria Prevention in UK Travellers
May 6, 2017·Trends in Pharmacological Sciences·Jigang WangSteven R Meshnick
Apr 14, 2019·Seminars in Perinatology·Melissa BausermanSteve Meshnick

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