Suspecting Hyperferritinemic Sepsis in Iron-Deficient Population: Do We Need a Lower Plasma Ferritin Threshold?

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Swarup GhoshKarthi Nallasamy

Abstract

Hyperferritinemia is being suggested to identify patients with sepsis-induced macrophage activation syndrome for early intervention. However, data among iron-deficient children are scarce. This study was planned to explore the biological behavior of plasma ferritin in children from communities with a high frequency of iron deficiency with septic shock and its association with the outcome. Prospective observational study. Tertiary care teaching hospital in a low-middle income economy of South Asia. Patients (6 mo to 12 yr) (n = 42) with septic shock and their healthy siblings as controls (n = 36). Patients/controls with blood transfusion/iron supplement during last 6 months or with any chronic disease were excluded. None. Ferritin was measured in patients at enrollment and then at 1 month of hospital discharge while they were not on iron supplementation and in controls as indicative of baseline level. Patients' median age was 30 months (13.5-87 mo), 31% were malnourished, majority (86%) had anemia, and two thirds had microcytic hypochromic red cells. Ferritin at admission was 763 ng/mL (480-1,820 ng/mL) in nonsurvivors, whereas 415 ng/mL (262-852 ng/mL) in survivors (p = 0.11). Pediatric Logistic Organ Dysfunction score and C-re...Continue Reading

References

Nov 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·R BaynesN Mansoor
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Aug 29, 2006·Pediatric Blood & Cancer·Jan-Inge HenterGritta Janka
Nov 16, 2007·Acta Paediatrica·Pedro Celiny Ramos GarciaRobert Charles Tasker
Dec 19, 2007·Pediatric Blood & Cancer·Carl E AllenKenneth L McClain
Mar 28, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Leticia Castillo, Joseph Carcillo
Jan 26, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Tellen D BennettThomas V Brogan
Jun 21, 2011·Indian Journal of Community Medicine : Official Publication of Indian Association of Preventive & Social Medicine·Prakash V Kotecha
Jan 28, 2012·American Journal of Respiratory and Critical Care Medicine·Shailaja J HaydenErik R Swenson
Jun 22, 2012·Critical Care : the Official Journal of the Critical Care Forum·Demet DemirkolUNKNOWN Turkish Secondary HLH/MAS Critical Care Study Group
Apr 25, 2013·Cold Spring Harbor Perspectives in Medicine·Jeffery L Miller
Mar 4, 2015·American Journal of Respiratory and Critical Care Medicine·Scott L WeissUNKNOWN Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investiga
Jul 15, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph A CarcilloBradley S Podd
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Aug 18, 2016·Frontiers in Pediatrics·E Scott HalsteadScott L Weiss
Sep 28, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Karthik Narayanan RamaswamyKarthi Nallasamy
Dec 13, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph A CarcilloUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Feb 6, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ricardo Garcia Branco, Pedro Celiny Ramos Garcia
Apr 15, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph A CarcilloUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Aug 5, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jhuma SankarRameshwar S Meena

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Nov 7, 2019·Current Pharmaceutical Design·Joanna Giemza-StokłosaPrzemysław J Kotyla
Jul 10, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Srinivas Murthy, Niranjan Kissoon
Sep 6, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Namita Ravikumar, Arun K Baranwal
Oct 4, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cristian T Tonial, Pedro Celiny R Garcia
Oct 4, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Pusp Raj Awasthi, Suresh Kumar Angurana
Apr 29, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Cristian T TonialPedro Celiny R Garcia
Jan 1, 2021·Journal of Tropical Pediatrics·Kumar Manish RajArushi Gahlot Saini
Nov 14, 2020·Expert Review of Molecular Diagnostics·Evdoxia Kyriazopoulou, Evangelos J Giamarellos-Bourboulis
Sep 30, 2020·Jornal de pediatria·Cristian Tedesco TonialPedro Celiny Ramos Garcia
Mar 25, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Arun K BaranwalPraveen Kumar-M
Dec 8, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Arun K BaranwalPramod K Gupta

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