Sustainable method for Alzheimer dementia prediction in mild cognitive impairment: Electroencephalographic connectivity and graph theory combined with apolipoprotein E

Annals of Neurology
Fabrizio VecchioPaolo M Rossini

Abstract

Mild cognitive impairment (MCI) is a condition intermediate between physiological brain aging and dementia. Amnesic-MCI (aMCI) subjects progress to dementia (typically to Alzheimer-Dementia = AD) at an annual rate which is 20 times higher than that of cognitively intact elderly. The present study aims to investigate whether EEG network Small World properties (SW) combined with Apo-E genotyping, could reliably discriminate aMCI subjects who will convert to AD after approximately a year. 145 aMCI subjects were divided into two sub-groups and, according to the clinical follow-up, were classified as Converted to AD (C-MCI, 71) or Stable (S-MCI, 74). Results showed significant differences in SW in delta, alpha1, alpha2, beta2, gamma bands, with C-MCI in the baseline similar to AD. Receiver Operating Characteristic(ROC) curve, based on a first-order polynomial regression of SW, showed 57% sensitivity, 66% specificity and 61% accuracy(area under the curve: AUC=0.64). In 97 out of 145 MCI, Apo-E allele testing was also available. Combining this genetic risk factor with Small Word EEG, results showed: 96.7% sensitivity, 86% specificity and 91.7% accuracy(AUC=0.97). Moreover, using only the Small World values in these 97 subjects, the RO...Continue Reading

Associated Clinical Trials

Aug 31, 2018·Paolo Maria Rossini

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Citations

Feb 23, 2019·Frontiers in Human Neuroscience·Fernando MaestúPaul E Schulz
Apr 9, 2019·Journal of Alzheimer's Disease : JAD·Angelo BianchettiStefania Maggi
Oct 23, 2019·Network Neuroscience·Linda DouwCornelis J Stam
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Nov 27, 2020·Brain Research Bulletin·Francesca MiragliaPaolo Maria Rossini
Dec 1, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Francesca MiragliaPaolo Maria Rossini
Mar 4, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Dennis A TurnerCarol A Colton
May 18, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark HallettPaolo M Rossini
May 4, 2021·Frontiers in Human Neuroscience·Qiang XuRongfeng Qi
Jun 8, 2021·NeuroImage. Clinical·Giordano CecchettiMassimo Filippi
Jun 8, 2021·Journal of Alzheimer's Disease : JAD·Fabrizio VecchioPaolo Maria Rossini
Jul 6, 2021·Aging and Disease·Dennis A Turner
Aug 28, 2021·Brain Sciences·Ali H Al-NuaimiEmmanuel Ifeachor
Jul 4, 2021·Statistics in Medicine·Dustin PlutaZhaoxia Yu

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