Sustainable replication and coevolution of cooperative RNAs in an artificial cell-like system

Nature Ecology & Evolution
Ryo Mizuuchi, Norikazu Ichihashi

Abstract

Cooperation among independently replicating molecules is a key phenomenon that allowed the development of complexity during the early evolution of life. Generally, this process is vulnerable to parasitic or selfish entities, which can easily appear and destroy such cooperation. It remains unclear how this fragile cooperation process appeared and has been sustained through evolution. Theoretical studies have indicated that spatial structures, such as compartments, allow sustainable replication and the evolution of cooperative replication, although this has yet to be confirmed experimentally. In this study, we constructed a molecular cooperative replication system, in which two types of RNA, encoding replication or metabolic enzymes, cooperate for their replication in compartments, and we performed long-term replication experiments to examine the sustainability and evolution of the RNAs. We demonstrate that the cooperative relationship of the two RNAs could be sustained at a certain range of RNA concentrations, even when parasitic RNA appeared in the system. We also found that more efficient cooperative RNA replication evolved during long-term replication through seemingly selfish evolution of each RNA. Our results provide experi...Continue Reading

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Citations

Jan 31, 2019·Life·Jai A Denton, Chaitanya S Gokhale
Apr 9, 2019·Annals of the New York Academy of Sciences·Norikazu Ichihashi
May 1, 2019·Chembiochem : a European Journal of Chemical Biology·Kensuke UedaNorikazu Ichihashi
Oct 1, 2019·Nucleic Acids Research·Laura I WeiseHannes Mutschler
May 6, 2020·Nature Communications·Madison S KriegerMartin A Nowak
Jul 11, 2020·Advanced Biosystems·Kristian Le VayHannes Mutschler
Aug 29, 2018·Nature Ecology & Evolution·Ricard Solé
Oct 13, 2020·Chemical Communications : Chem Comm·Ryo Mizuuchi, Norikazu Ichihashi
Nov 27, 2020·Chemical Communications : Chem Comm·Kai Libicher, Hannes Mutschler
May 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yei-Chen LaiIrene A Chen
May 18, 2021·Computational and Structural Biotechnology Journal·Adriano CaliariTetsuya Yomo
Jul 1, 2020·ACS Synthetic Biology·Peng ZhangYuan Lu
Nov 8, 2019·Journal of the American Chemical Society·Kosaku NobaKatsutoshi Hori

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Methods Mentioned

BETA
PCR
electrophoresis
in vitro transcription
column chromatography

Software Mentioned

ViennaRNA
scipy

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