Sustained administration of bupropion alters the neuronal activity of serotonin, norepinephrine but not dopamine neurons in the rat brain

Neuropharmacology
Mostafa El MansariPierre Blier

Abstract

Bupropion is widely used in the treatment of depression. There are, however, limited data on its long-term effects on monoaminergic neurons and therefore the mechanism of its delayed onset of action is at present not well understood. The present study was conducted to examine the effects of prolonged bupropion administration on the firing activity of dorsal raphe nucleus (DRN), locus coeruleus (LC), and ventral tegmental area (VTA) neurons. Spontaneously firing neurons were recorded extracellularly in rats anesthetized with chloral hydrate. Bupropion (30 mg/kg/day) was administered using subcutaneously implanted minipumps. In the DRN, the firing rate of serotonin (5-HT) neurons was significantly increased after 2, 7 and 14 days of administration. The suppressant effect of LSD was significantly diminished after the two-day regimen, indicating a desensitization of 5-HT1A autoreceptors. In the LC, the firing rate of norepinephrine (NE) neurons was significantly attenuated after a 2-day regimen, but recovered progressively over 14 days of administration. The suppressant effect of clonidine on NE neuronal firing was significantly attenuated in rats treated with bupropion for 14 days, indicating a desensitization of alpha2-adrenocept...Continue Reading

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Citations

Dec 17, 2009·Psychopharmacology·Tatiana Lipina, John Roder
Oct 29, 2011·European Archives of Psychiatry and Clinical Neuroscience·Thomas C BaghaiUNKNOWN Section of Pharmacopsychiatry, World Psychiatric Association
Mar 20, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Elizabeth L ThorpeJessica Boyer
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Pierre Blier
Sep 23, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sakina J Rizvi, Sidney H Kennedy
Apr 22, 2010·CNS Neuroscience & Therapeutics·Mostafa El MansariPierre Blier
Jul 26, 2011·Biochemical Pharmacology·Michael Paolini, Mariella De Biasi
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Mostafa El MansariPierre Blier
May 24, 2011·Journal of Affective Disorders·Konstantinos N FountoulakisHagop Akiskal
Jul 12, 2014·Journal of Affective Disorders·Gerard E BruderPatrick J McGrath
Oct 25, 2012·Neuroscience and Biobehavioral Reviews·Ulrich Hegerl, Tilman Hensch
Dec 4, 2012·The International Journal of Neuropsychopharmacology·Heiko GrafMartin Walter
Sep 13, 2011·The International Journal of Neuropsychopharmacology·Franck ChenuPierre Blier
Jun 12, 2013·The International Journal of Neuropsychopharmacology·Pierre Blier
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