Sustained antiretroviral treatment adherence in survivors of the pre-HAART era: attitudes and beliefs

AIDS Care
C R FumazB Clotet

Abstract

The objective of this study was to assess adherence of HIV-1-infected patients who started treatment in the pre-HAART era and to determine variables associated with better adherence, including relevant attitudes and beliefs. This is a cross-sectional study enrolling patients who had received antiretroviral therapy for >or=10 years. Adherence was evaluated through self-reporting and plasma drug concentrations. Treatment variables, attitudes and beliefs were collected during structured interviews. The results show that for 87 patients the median (interquartile range) time on therapy was 13 (10-19) years; 80 were on therapy at the time of analysis. Adherence was >or=95% in 54 patients (67.5%), 90-94% in 22 (27.5%) and <90% in 4 (5%). Drug concentrations were below the lower limit of detection in five patients. Younger age (p=0.014), female gender (p=0.005), current substance abuse (p=0.004) and hepatitis C virus co-infection (p<0.001) were related to lower adherence. Adherence did not differ in relation to different drug families or once- or twice-daily regimens. Patients with adherence <95% were more likely to have interrupted treatment without doctor's recommendation (p=0.009). Adherent patients exhibited a higher perception of ...Continue Reading

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Citations

Jun 13, 2009·AIDS Patient Care and STDs·Carmina R FumazBonaventura Clotet
Jun 12, 2012·AIDS Patient Care and STDs·Andrea NelsenAanand D Naik
Dec 4, 2012·Patient Preference and Adherence·Colleen A McHorneyXiaoquan Zhao
Feb 7, 2013·International Journal of Behavioral Medicine·Erica ShreckElizabeth A Walker
Dec 14, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Carmina R FumazBonaventura Clotet
Apr 7, 2011·AIDS and Behavior·Carmen OrtegoJavier Vejo
May 7, 2011·Gaceta sanitaria·Carmen OrtegoFrancisco Javier Llorca
Aug 1, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Aline Santarem ErnestoMarcos Tadeu Nolasco da Silva

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