PMID: 11925353Apr 2, 2002Paper

Sustained attention deficit in bipolar disorder

The British Journal of Psychiatry : the Journal of Mental Science
Luke ClarkGuy M Goodwin

Abstract

Recovery in bipolar disorder is central to its definition but is rarely complete. Previous work has suggested that neuropsychological impairment persists during the euthymic state but has been confounded partly by mild affective symptoms in remitted patients. To characterise neuropsychological functioning in the euthymic phase of bipolar disorder with an emphasis on tasks of executive functioning. Thirty euthymic patients with bipolar disorder were compared with thirty healthy controls on neuropsychological tasks differentially sensitive to damage within prefrontal cortex. Bipolar I patients were impaired on tasks of attentional set shifting, verbal memory and sustained attention. Only sustained attention deficit survived controlling for mild affective symptoms. This deficit was related to progression of illness, but was none the less present in a subgroup of patients near illness onset. Sustained attention deficit may represent a neuropsychological vulnerability marker for bipolar disorder, providing a focus for further understanding of the phenotype and analysis of the neuronal networks involved.

References

Jun 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson, A O'Connell
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
May 1, 1992·Journal of Affective Disorders·M P AustinG M Goodwin
Feb 1, 1991·Journal of Abnormal Psychology·M F LenzenwegerM Putnick
Nov 1, 1990·Archives of General Psychiatry·T E GoldbergD R Weinberger
Jun 1, 1990·Biological Psychiatry·J A CoffmanH A Nasrallah
Jul 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·R Morice
Jun 1, 1971·Psychological Bulletin·J B Grier
Nov 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·J Scott
Jan 1, 1997·Biological Psychiatry·J C Soares, J J Mann
Feb 28, 1997·Schizophrenia Research·J Addington, D Addington
Jan 1, 1997·Depression and Anxiety·S A HlastalaD J Kupfer
Dec 24, 1997·Psychological Medicine·R PurcellC Pantelis
Jan 19, 1999·The American Journal of Psychiatry·K W SaxJ M Hawkins
Dec 22, 1999·Psychotherapy and Psychosomatics·A Martínez-AránM Salamero
Dec 30, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M EnbomA Linde
Jan 25, 2000·The British Journal of Psychiatry : the Journal of Mental Science·I N FerrierJ Scott
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Apr 2, 2010·Psychopharmacology·Christina L NemethWilliam A Carlezon
Jul 17, 2010·Applied Psychophysiology and Biofeedback·Estate M SokhadzeRif S El-Mallakh
Feb 2, 2013·Cognitive Neurodynamics·E BaşarA Ozerdem
Nov 13, 2004·Current Psychiatry Reports·Samuel R Chamberlain, Barbara J Sahakian
Oct 19, 2004·Journal of Affective Disorders·Petra Weiland-FiedlerAlexander Neumeister
Jan 7, 2004·Biological Psychiatry·Daniel P DicksteinEllen Leibenluft
Oct 18, 2003·Journal of Psychiatric Research·Rafael Tabarés-SeisdedosManuel Gómez-Beneyto
Nov 27, 2002·Journal of Affective Disorders·Seema Quraishi, Sophia Frangou
Jul 16, 2003·Psychiatry Research·Beatriz López-Luengo, Carmelo Vázquez
May 3, 2007·Psychological Medicine·Samuel D R StoddartLisa A Jones
Dec 25, 2008·Psychological Medicine·J McKirdyA M McIntosh
Sep 24, 2010·Psychological Medicine·D J MartinoF Manes
Oct 27, 2006·Development and Psychopathology·Daniel P Dickstein, Ellen Leibenluft
Jun 21, 2005·Journal of the International Neuropsychological Society : JINS·Eric R LarsonStephen M Strakowski
Mar 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Koji MatsuoJair C Soares
Jun 23, 2005·Molecular Psychiatry·G M MacQueenM Alda
Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P RoiserBarbara J Sahakian
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Birgit AblerStephan Heckers
Mar 14, 2007·Cognitive Neuropsychiatry·Mary L Phillips
Feb 28, 2008·Cognitive Neuropsychiatry·J K TrivediRajul Tandon
Oct 24, 2012·Cognitive Neuropsychiatry·Tamsyn E Van Rheenen, Susan L Rossell
Nov 8, 2011·Journal of Clinical and Experimental Neuropsychology·Tyler ShawGerald Matthews
May 5, 2005·The Journal of Nervous and Mental Disease·Amanda OlleyMarie-Paule V Austin
Nov 24, 2011·Journal of Psychiatric Practice·Jonathan P StangeThilo Deckersbach
Nov 15, 2007·The Journal of Nervous and Mental Disease·Catherine M CahillGin S Malhi
Jul 1, 2011·The Journal of Nervous and Mental Disease·Diego J MartinoSergio A Strejilevich
Feb 3, 2012·The Journal of Nervous and Mental Disease·Guillermo LaheraAlberto Fernández-Liria
Dec 10, 2009·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Chiara VolpatoCarlo Semenza
Dec 5, 2006·Current Opinion in Psychiatry·John F Cryan, David A Slattery
Nov 17, 2012·Current Opinion in Psychiatry·Christina Andreou, Vasilis P Bozikas
Mar 22, 2005·The Australian and New Zealand Journal of Psychiatry·Antoni BenabarreManuel Valdés
Apr 17, 2008·Psychiatry and Clinical Neurosciences·Jitendra K TrivediRajul Tandon
Oct 28, 2008·Psychiatry and Clinical Neurosciences·Basant K PradhanAnupama Mankotia
Jun 9, 2005·Epilepsia·Sophia Frangou
Jun 1, 2006·Acta Neuropsychiatrica·Melissa J Green, Gin S Malhi
Apr 30, 2009·Annual Review of Neuroscience·Luke ClarkBarbara J Sahakian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.