Sustained benefit from intravenous immunoglobulin therapy for gastrointestinal involvement in systemic sclerosis

Rheumatology
Jasmin RajaVoon H Ong

Abstract

IVIG is known to confer significant benefit in rheumatologic conditions, including inflammatory myopathy. This study aimed to assess the efficacy of IVIG across different aspects of internal organ involvement in refractory active SSc, particularly the gastrointestinal (GI) system. SSc patients with overlap polymyositis who remained active and unresponsive to conventional disease-modifying agents and who subsequently received IVIG were identified. GI symptoms were assessed using validated questionnaires. The Medical Research Council Sum Score for muscle strength and modified Rodnan skin score (mRSS) were assessed. Serial measurements were undertaken at baseline prior to the first IVIG treatment and post-treatment in the most recent assessment. Fifteen SSc patients were consecutively recruited into this observational study. The mean duration of IVIG treatment was 2.3 years, with treatment frequency ranging from every 6 weeks to 4 months. Compared with baseline, there was a significant reduction in gastro-oesophageal reflux frequency and intensity mean scores (P = 0.006 and P = 0.013, respectively). Significant improvement in the Gastrointestinal Tract (GIT) 2.0 score from a baseline mean score of 1.07 (s.d. 0.67) to 0.60 (0.46) (...Continue Reading

References

Nov 1, 1994·Clinical Immunology and Immunopathology·D AmranE W Gelfand
Jan 1, 1995·Arthritis and Rheumatism·M Qi, J A Schifferli
Jan 5, 2006·Clinical Reviews in Allergy & Immunology·Vered MolinaYehuda Shoenfeld
May 2, 2008·Health and Quality of Life Outcomes·Michael ShawFolke Johnsson
Sep 26, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jagmohan SinghSatish Rattan

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Citations

Nov 1, 2016·Zeitschrift für Rheumatologie·T Witte
Feb 22, 2018·Digestive Diseases and Sciences·Lazaros I SakkasSpyros Potamianos
Sep 21, 2018·Current Opinion in Rheumatology·Zsuzsanna H McMahan, Laura K Hummers
Jan 31, 2017·Journal of Scleroderma and Related Disorders·Andrew B ShreinerDinesh Khanna
Jul 10, 2019·Current Gastroenterology Reports·Beena Sattar, Reena V Chokshi
Mar 25, 2020·Current Opinion in Rheumatology·David Roofeh, Dinesh Khanna
Apr 12, 2017·Current Rheumatology Reports·Cristiano Sacchetti, Nunzio Bottini
Dec 3, 2016·Expert Review of Clinical Immunology·Cosimo BruniMarco Matucci-Cerinic
Oct 12, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Estelle T Spear, Gary M Mawe
May 27, 2020·Wiener klinische Wochenschrift·Dijana PerkovićDušanka Martinović Kaliterna
Dec 16, 2020·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·A BrandUNKNOWN European Mediterranean Initiative for Transfusion Medicine
Jan 16, 2021·Clinical Reviews in Allergy & Immunology·Ming ZhaoQianjin Lu
Apr 29, 2021·Rheumatology·Fiza AhmedChristopher P Denton
Jul 27, 2021·Current Treatment Options in Gastroenterology·Z H McMahan, D Khanna

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