Sustained clinical improvement of Parkinson's disease in two patients with facially-transplanted adipose-derived stromal vascular fraction cells.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Michael CarstensDiego Correa

Abstract

Cell-based therapy has been studied as an alternative for Parkinson's Disease (PD), with different routes of administration. The superficial fascia and facial muscles possess a rich blood supply, while venous and lymphatic access via the orbit and the cribriform plate provide a route to cerebral circulation. We here document positive clinical effects in two patients with PD treated with autologous adipose-derived stromal vascular fraction (SVF) cell preparation, implanted into the face and nasal cavity. Two patients with PD were transplanted with 60 million total nucleated cells in processed SVF into the facial muscles and nose. Serial evaluations were carried out up to 5 years (patient 1) and 1 year (patient 2), using the PDQ-39, the UPDRS, and serial videos. Video scoring was reviewed in a blinded fashion. Both patients reported qualitative improvement in motor and nonmotor symptoms following injection. Quantitatively, PDQ-39 scores decreased in all categories for both. On-medication UPDRS motor scores decreased in both (20 to 4 in patient 1, 18 to 3 in patient 2) despite taking the same or less medication (LEDD 350 to 350 in patient 1, LEDD 1175 to 400 in pt2). Both subjects had off-medication UPDRS scores similar to their p...Continue Reading

References

Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Apr 10, 2008·Cell Stem Cell·Paolo BiancoPaul J Simmons
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Jul 6, 2011·Cell Stem Cell·Arnold I Caplan, Diego Correa
Oct 26, 2013·Neuro-degenerative Diseases·Keun-A ChangYoo-Hun Suh
Jan 1, 2014·The European Journal of Neuroscience·Simon R W Stott, Roger A Barker
Sep 19, 2014·Cell Biology International·Hojjat Naderi-MeshkinNaghmeh Ahmadiankia
Oct 9, 2014·Annual Review of Physiology·Stella Kourembanas
Apr 2, 2015·Clinics in Plastic Surgery·Sahil K KapurAdam J Katz
Sep 30, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Olle Lindvall
Nov 8, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·James GuoAlan D Widgerow
Nov 14, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Andrew NguyenAlan D Widgerow
Nov 26, 2015·BMC Biology·Iain R Murray, Bruno Péault
Mar 30, 2016·World Journal of Stem Cells·Ann De Becker, Ivan Van Riet
May 15, 2018·Cell Transplantation·Carlos GaleanoPeter J Hornsby
Nov 24, 2018·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·T SandulescuW-H Arnold
Jun 17, 2019·Reviews in the Neurosciences·Mahasweta DasSubhra Mohapatra

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