Sustained efficacy of adjuvant immunotherapy with cytokine-induced killer cells for hepatocellular carcinoma: an extended 5-year follow-up

Cancer Immunology, Immunotherapy : CII
Jeong-Hoon LeeJung-Hwan Yoon

Abstract

Our earlier multicenter randomized controlled trial showed that adjuvant immunotherapy with cytokine-induced killer (CIK) cells resulted in longer recurrence-free survival (RFS) and overall survival (OS) as well in patients who received curative treatment for hepatocellular carcinoma (HCC). In the present study, we determined if the efficacy of CIK cell therapy continued after end of repeated CIK cell injections. We performed a follow-up study of our preceding trial. We included 226 patients: 114 patients in the immunotherapy group (injection of 6.4 × 109 CIK cells, 16 times during 60 weeks) and 112 patients in the control group (no treatment) after potentially curative treatment for HCC. In total, 162 patients (89 of the immunotherapy group and 73 of controls) underwent an extended follow-up for 60 months after randomization of the last patient. The primary endpoint was RFS, and secondary endpoints included OS. During follow-up time of median 68.5 months (interquartile range 45.0-82.2 months), the immunotherapy group continued to show a significantly lower risk of recurrence or death [hazard ratio (HR) 0.67; 95% confidence interval (CI) 0.48-0.94; P = 0.009 by one-sided log-rank test]. At 5 years, RFS rate was 44.8% in the imm...Continue Reading

References

Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G EberlH R MacDonald
Jan 5, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·M R VernerisJ A Shizuru
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne-Sophie DugastBernard Vanhove
Sep 27, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Dong HuiKong Da-Lu
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Miny SamuelKhee-Chee Soo
Feb 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Megan A CooperWayne M Yokoyama
Nov 12, 2009·Annals of Surgical Oncology·Ho Geun YounSung Kim
Jan 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rossana TallericoEnnio Carbone
Mar 5, 2013·The Journal of Clinical Investigation·David Vasquez-DunddelYoung Kim
Jun 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eun Ju ChoHyo-Suk Lee
May 30, 2014·The Lancet Oncology·Sébastien AnguilleZwi N Berneman
Sep 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erik AmesWilliam J Murphy
Jan 29, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie K HeimbachJorge A Marrero
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver

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Citations

Aug 28, 2019·Medicina·Ali AlqahtaniDanae M Hammouda
Jun 7, 2019·World Journal of Gastroenterology : WJG·Changhoon ChoiHee Chul Park
May 31, 2019·Journal of Hematology & Oncology·Eishiro Mizukoshi, Shuichi Kaneko
Oct 21, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Saleh A AlqahtaniWaleed K Al-Hamoudi
Nov 26, 2020·Cellular & Molecular Immunology·Benjamin RufTim F Greten
Mar 24, 2021·Frontiers of Medicine·Wei ZhangXiao-Ping Chen
Apr 24, 2021·World Journal of Gastrointestinal Oncology·Ming-Cheng GuanTian Yang
Jun 5, 2021·Journal of Biomedical Nanotechnology·Hongbo NiMeng Niu
Jun 17, 2021·World Journal of Clinical Oncology·Konstantinos DamirisNikolaos Pyrsopoulos
Aug 28, 2021·International Journal of Molecular Sciences·Nicolas JacquelotPamela S Ohashi

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