Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

Neuro-oncology
Roshan MahabirShinya Tanaka

Abstract

Ionizing irradiation is an effective treatment for malignant glioma (MG); however, a higher rate of recurrence with more aggressive phenotypes is a vital issue. Although epithelial-mesenchymal transition (EMT) is involved in irradiation-induced cancer progression, the role for such phenotypic transition in MG remains unknown. To investigate the mechanism of irradiation-dependent tumor progression in MG, we performed immunohistochemistry (IHC) and qRT-PCR using primary and recurrent MG specimens, MG cell lines, and primary culture cells of MG. siRNA technique was used for MG cell lines. In 22 cases of clinically recurrent MG, the expression of the mesenchymal markers vimentin and CD44 was found to be increased by IHC. In paired identical MG of 7 patients, the expression of collagen, MMPs, and YKL-40 were also elevated in the recurrent MGs, suggesting the The Cancer Genome Atlas-based mesenchymal subtype. Among EMT regulators, sustained elevation of Snail was observed in MG cells at 21 days after irradiation. Cells exhibited an upregulation of migration, invasion, numbers of focal adhesion, and MMP-2 production, and all of these mesenchymal features were abrogated by Snail knockdown. Intriguingly, phosphorylation of ERK1/2 and GS...Continue Reading

References

Oct 23, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J EhrhartM H Barcellos-Hoff
Jun 24, 2000·Molecular and Cellular Biology·K HemavathyY T Ip
Sep 29, 2000·Biochemical Pharmacology·B BoyerN Edme
Apr 6, 2002·Canadian Journal of Physiology and Pharmacology·Bruce E ElliottAlan B Tuck
Aug 30, 2003·Oncogene·Paul DentSteven Grant
Sep 9, 2005·Nature Reviews. Cancer·Thomas BrabletzThomas Kirchner
Dec 6, 2005·Hematology/oncology Clinics of North America·Raphael Bueno
May 26, 2006·Nature·Jacques PouysségurNathalie M Mazure
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher E PelloskiKenneth D Aldape
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carmen TimkePeter E Huber
Aug 7, 2008·PloS One·Anne-Pierre MorelAlain Puisieux
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kunal RehaniMichael Martin
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri
Sep 3, 2009·Cell Structure and Function·Kaori TsutsumiYusuke Ohba
Dec 25, 2009·Nature·Maria Stella CarroAntonio Iavarone
Jun 23, 2010·BMC Cancer·Hong Wei YangMark D Johnson
Jul 22, 2010·Molecular Cancer·Svetlana A MikheevaRobert C Rostomily
Jan 11, 2011·Cancer Cell International·William W Harless
Jan 13, 2011·Cellular and Molecular Neurobiology·Sung-Pil HanSae-Ock Oh
Jun 15, 2011·Carcinogenesis·Jin-Yuan Shih, Pan-Chyr Yang
Jun 17, 2011·Neoplasia : an International Journal for Oncology Research·Mengxian ZhangPeter E Huber
Dec 23, 2011·Genes & Development·Krishna P L BhatKenneth D Aldape
Dec 27, 2011·Free Radical Biology & Medicine·Devipriya NagarajanWeiling Zhao
Apr 26, 2012·Molecular Cancer Therapeutics·Shinji KohsakaShinya Tanaka
May 9, 2012·Nucleic Acids Research·Sabine StolzenburgPilar Blancafort
Jun 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna L SmithHeide L Ford

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Citations

May 11, 2015·FEBS Letters·Laia CajaAristidis Moustakas
Apr 8, 2015·International Journal of Oncology·Carolin KubeltJanka Held-Feindt
Dec 19, 2014·Brain Pathology·Ulf D KahlertCharles G Eberhart
Mar 17, 2016·Journal of Neuropathology and Experimental Neurology·Abigail K SuwalaJaroslaw Maciaczyk
May 11, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Andrew MorokoffAndrew H Kaye
Aug 19, 2014·Asian Pacific Journal of Tropical Medicine·Pei-Dong LiZhen Wang
May 14, 2016·Neurologia Medico-chirurgica·Tomotsugu IchikawaIsao Date
Jul 30, 2016·Nature Communications·C DepnerA Acker-Palmer
Sep 3, 2016·Seminars in Cancer Biology·Gaia CantelliVictoria Sanz-Moreno
Jan 18, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michal ZaidenAyelet David
Jun 2, 2017·International Journal of Cancer. Journal International Du Cancer·Nusrat JahanHiroaki Wakimoto
Jun 5, 2018·PloS One·Pascaline Nguemgo KouamHelmut Bühler
Feb 22, 2018·Glia·Valéria Pereira FerrerRolf Mentlein
Aug 31, 2018·Journal of Cellular Physiology·Haiwen MaXuejun Yang
Sep 25, 2018·Pathology International·Shunya TanakaKoji Iihara
Mar 4, 2017·Scientific Reports·Jiejing LiShuo Wei
Feb 23, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Deborah RotoliPablo Martín-Vasallo
Sep 15, 2018·Journal of Cellular Biochemistry·Chao ChenJianmin Liu
Feb 6, 2020·International Journal of Molecular Sciences·Aleksandra Ellert-MiklaszewskaBozena Kaminska
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hongchao PanMelitta Schachner
Aug 20, 2017·Cellular and Molecular Life Sciences : CMLS·Shwetal Mehta, Costanza Lo Cascio
Sep 16, 2019·Journal of Translational Medicine·Shuaishuai XuLiang Liu
Mar 22, 2016·Oncology Letters·Yasuo Iwadate
Mar 23, 2017·Drugs in R&D·Dorota Lubanska, Lisa Porter
Jul 22, 2017·Oncology Reports·Tingting ZhangYuqian Zhao
Aug 16, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Takayuki YasudaTakakazu Kawamata
Apr 13, 2018·International Journal of Molecular Sciences·Ching-Ann LiuHorng-Jyh Harn

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