Sustained exercise hyperemia during prolonged adenosine infusion in humans

Physiological Reports
Sushant M RanadiveMichael J Joyner

Abstract

The contribution of Adenosine (ADO) to exercise hyperemia remains controversial and it is unknown whether ADO can evoke the prolonged vasodilation seen during exercise bouts. Therefore, we tested hypotheses in the human forearm during 3 h of intra-arterial high dose ADO infusion: (1) skeletal muscle blood flow would wane over time; (2) exercise hyperemic responses during ADO administration would be unaffected compared to baseline. Using sodium nitroprusside (SNP), we tested parallel hypotheses regarding nitric oxide (NO) in a separate group of participants. Seventeen young healthy participants (ADO: n = 9; SNP: n = 8) performed multiple rhythmic handgrip exercise bouts (20% of maximum), two during saline and five during 3 h of continuous drug infusion. Five minutes of ADO infusion resulted in a ~5-fold increase in forearm vascular conductance (FVC; 4.8 ± 0.6 vs. 24.2 ± 3.2 mL/min/100 mmHg, P < 0.05). SNP caused a ~4-fold increase (4.4 ± 0.6 vs. 16.6 ± 2 mL/min/100 mmHg, P < 0.05). FVC did not wane over time with ADO (24.2 ± 3.2 and 22 ± 1.2 mL/min/100 mmHg [P > 0.05]) or SNP (16.6 ± 2 and 14.1 ± 2.4 mL/min/ 100 mmHg [P > 0.05]) at 5 versus 150 min. Superimposed exercise during ADO or SNP infusions evoked marked and consistent a...Continue Reading

References

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Jun 22, 2013·Journal of Applied Physiology·Darren P CaseyMichael J Joyner
Jun 29, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Anne R CreceliusFrank A Dinenno
Sep 23, 2014·Journal of Applied Physiology·Sushant M RanadiveDarren P Casey
May 30, 2015·Journal of Applied Physiology·Darren P CaseyMichael J Joyner
Jul 23, 2016·Journal of Applied Physiology·John R A ShepherdSushant M Ranadive

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Citations

Jan 12, 2021·Physiological Reports·Timothy R RotariusBarry W Scheuermann

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