Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sophia T PapadeasG R Breese

Abstract

Extracellular signal-regulated kinase (ERK) 1/2, a well known regulator of gene expression, is likely to contribute to signaling events underlying enduring neural adaptations. Phosphorylated (phospho)-ERK was examined immunohistochemically after both single and repeated (i.e., sensitizing) doses of the partial D1-dopamine (DA) receptor agonist SKF-38393 (2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benazepine HCl) to adult rats lesioned as neonates (neonate lesioned) with 6-hydroxydopamine. Remarkably, prolonged phospho-ERK accumulated primarily in layers II-III of medial prefrontal cortex (MPC), where it declined gradually yet remained significantly elevated for at least 36 d after repeated doses of SKF-38393. Sustained (> or =7 d) phospho-ERK was observed for shorter periods in various other cortical regions but was not detectable in striatum or nucleus accumbens. At 36 d, an additional injection of SKF-38393 to sensitized rats restored phospho-ERK to maximal levels only in MPC when examined 7 d later. Phosphorylated cAMP response element-binding protein (CREB), examined 7 d after the sensitizing regimen, was observed exclusively in MPC, where it was abundant throughout all layers. Systemic injections of SL327 (alpha-[amino...Continue Reading

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Citations

Mar 7, 2008·Cerebral Cortex·Horst SchicknickWolfgang Tischmeyer
Oct 19, 2006·Developmental Neuroscience·Bonita L BlakeH A Jinnah
Jan 6, 2007·Brain and Cognition·Stacy A Castner, Graham V Williams
Nov 28, 2006·The Annals of Thoracic Surgery·Tatiana ZaitsevaAnna Pastuszko
Oct 5, 2006·Journal of Neurochemistry·John Q WangLimin Mao
Apr 5, 2007·Annals of the New York Academy of Sciences·Jelena M MilasinPiergiorgio Strata
Feb 15, 2005·Brain Research. Brain Research Reviews·George R BreeseBonita L Blake
Mar 30, 2006·Behavioural Brain Research·John L BeardMichael K Georgieff
Oct 6, 2007·Journal of Neuropathology and Experimental Neurology·Charleen T ChuKelly L Jordan-Sciutto
May 14, 2020·The FEBS Journal·Patrícia I Santos, Tiago F Outeiro
Apr 24, 2007·Neurotoxicity Research·Nicola SimolaAnna R Carta
Apr 24, 2007·The Journal of Nutrition·John L BeardByron C Jones

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