Sustained extrastriate cortical activation without visual awareness revealed by fMRI studies of hemianopic patients

Vision Research
Rainer GoebelP Stoerig

Abstract

Patients with lesions in the primary visual cortex (V1) may show processing of visual stimuli presented in their field of cortical blindness even when they report being unaware of the stimuli. To elucidate the neuroanatomical basis of their residual visual functions, we used functional magnetic resonance imaging in two hemianopic patients, FS and GY. In the first experiment, a rotating spiral stimulus was used to assess the responsiveness of dorsal stream areas. Although no response was detectable within denervated or destroyed early visual cortex, motion-sensitive areas (hMT+/V5) ipsilateral to the lesion showed a strong sustained hemodynamic response. In GY, this activation was at least as strong as that of his contralesional hMT+/V5 to the stimulus in the normal hemifield. In the second experiment, coloured images of natural objects were used to assess the responsiveness of ventral stream areas. Again, no activity was detectable in ipsilesional early visual areas, but extrastriate areas in the lateral occipital cortex (hMT+/V5 and LO) and within the posterior fusiform gyrus (V4/V8) showed a robust sustained hemodynamic response. In both experiments, we observed that ipsilesional areas responded to stimuli presented in either...Continue Reading

References

Nov 27, 1992·Science·R FendrichM S Gazzaniga
Apr 1, 1992·Brain : a Journal of Neurology·P Stoerig, A Cowey
Feb 1, 1991·Neuroreport·P GirardJ Bullier
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J V HaxbyS I Rapoport
Apr 1, 1991·Brain : a Journal of Neurology·S Zeki
Aug 3, 1989·Nature·C J LueckR S Frackowiak
Feb 1, 1987·Brain : a Journal of Neurology·L Weiskrantz
Dec 1, 1974·Brain : a Journal of Neurology·L WeiskrantzJ Marshall
Dec 1, 1974·Brain : a Journal of Neurology·J C Meadows
Dec 1, 1980·Brain : a Journal of Neurology·J L BarburV A Waterfield
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·L WeiskrantzA Sahraie
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·R MalachR B Tootell
Jan 1, 1995·International Journal of Technology Assessment in Health Care·M Milner
Jun 22, 1994·Proceedings. Biological Sciences·P J BrentK H Ruddock
Nov 1, 1993·Visual Neuroscience·P Stoerig
Dec 1, 1993·Brain : a Journal of Neurology·J L BarburS Zeki
Feb 22, 1997·Proceedings. Biological Sciences·A L FinlayK H Ruddock
Mar 1, 1997·Brain : a Journal of Neurology·P Stoerig, A Cowey
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·A SahraieM J Brammer
Apr 29, 1998·Brain : a Journal of Neurology·S Zeki, D H Ffytche
Dec 4, 1998·Science·G Tononi, G M Edelman
Mar 12, 1999·Consciousness and Cognition·S Grossberg
Apr 9, 1999·Nature Neuroscience·N HadjikhaniR B Tootell
Apr 24, 1999·Neuropsychologia·R W KentridgeL Weiskrantz
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·A IshaiJ V Haxby
Feb 13, 2001·Trends in Cognitive Sciences·A K. Engel, W Singer
Oct 1, 1963·Journal of Neurology, Neurosurgery, and Psychiatry·J M VANBUREN
Mar 1, 1997·Journal of Cognitive Neuroscience·C M WessingerM S Gazzaniga

❮ Previous
Next ❯

Citations

Oct 13, 2001·NMR in Biomedicine
Jul 31, 2008·Experimental Brain Research·Iona Alexander, Alan Cowey
Jul 2, 2009·Experimental Brain Research·Alan Cowey
Aug 20, 2010·Experimental Brain Research·Arash SahraieBrigitte Yip
Mar 24, 2012·Experimental Brain Research·Alan Cowey, Iona Alexander
Feb 15, 2005·Magnetic Resonance Imaging·Elia FormisanoRainer Goebel
Nov 26, 2010·Eye·H Bridge
Jun 25, 2010·Nature·Michael C SchmidDavid A Leopold
Apr 27, 2005·Nature Neuroscience·John-Dylan Haynes, Geraint Rees
Nov 13, 2001·The European Journal of Neuroscience·A Cowey, P Stoerig
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Arash SahraieLawrence Weiskrantz
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jan Van den StockBeatrice de Gelder
May 13, 2008·Brain : a Journal of Neurology·Holly BridgeAlan Cowey
Jun 5, 2008·Brain : a Journal of Neurology·Geraint Rees
Nov 22, 2012·Brain : a Journal of Neurology·Tim MartinKrystel R Huxlin
Apr 18, 2012·Cerebral Cortex·Ana B ChicaPaolo Bartolomeo
Apr 2, 2002·Neuroreport·Scott D SlotnickJohn Hart
Mar 7, 2006·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Masaki YoshidaEmmanuel Alain Cabanis
Jun 6, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Linda J LanyonJason J S Barton
Mar 31, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Geraint Rees
Sep 19, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·L HenrikssonS Vanni
Jun 22, 2012·Annual Review of Neuroscience·David A Leopold
Apr 8, 2004·Journal of Cognitive Neuroscience·Antony B MorlandAlidz Pambakian
Jun 23, 2005·Journal of Cognitive Neuroscience·Arni KristjánssonJon Driver
Apr 18, 2008·Journal of Cognitive Neuroscience·Petya D RadoevaGeoffrey K Aguirre
Mar 27, 2009·Journal of Cognitive Neuroscience·Marco TamiettoBeatrice de Gelder
Sep 5, 2008·PLoS Computational Biology·Michael CapalboRainer Goebel
Dec 14, 2011·PloS One·Jaap MunnekeGeorge R Mangun
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krystel R HuxlinMary Hayhoe
Dec 25, 2013·Experimental Brain Research·Alexandra FayelKarine Doré-Mazars
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Miguel Castelo-BrancoRainer Goebel
Jun 5, 2014·Journal of Cognitive Neuroscience·Roberto CecereElisabetta Làdavas
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael C SchmidDavid A Leopold
Sep 18, 2012·Revue neurologique·S Ajina, C Kennard
Dec 8, 2009·Brain and Cognition·Jaap MunnekeJan Theeuwes
Oct 1, 2008·Progress in Neurobiology·Zhicheng Lin, Sheng He
Aug 3, 2007·Neuropsychologia·Juha SilvantoVincent Walsh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.