Sustained G-->A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

The Journal of General Virology
J P VartanianS Wain-Hobson

Abstract

Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G-->A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.

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Citations

Jun 26, 2012·Virus Research·Redmond P SmythJohnson Mak
Feb 12, 2008·Virus Research·Renato S Aguiar, B Matija Peterlin
Apr 14, 2005·Virus Research·Prasert Auewarakul
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May 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rodolphe SuspèneJean-Pierre Vartanian
Dec 2, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Vincent PetitSimon Wain-Hobson
Sep 12, 2006·Nucleic Acids Research·Rodolphe SuspèneSimon Wain-Hobson
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