Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function

Psychoneuroendocrinology
J Megan GrayMatthew N Hill

Abstract

Sustained exposure to stress or corticosteroids is known to cause changes in brain endocannabinoid (eCB) signaling, such that tissue contents of the eCBs N-arachidonylethanolamine (AEA) are generally reduced while 2-arachidonoylglycerol (2-AG) levels increase. These changes in eCB signaling are important for many of the aspects of chronic stress, such as anxiety, reward sensitivity and stress adaptation, yet the mechanisms mediating these changes are not fully understood. We have recently found that the stress-related neuropeptide corticotropin-releasing hormone (CRH), acting through the CRH type 1 receptor (CRHR1), can reduce AEA content by increasing its hydrolysis by the enzyme fatty acid amide hydrolase (FAAH) as well as increase 2-AG contents. As extra-hypothalamic CRH is upregulated by chronic corticosteroid or stress exposure, we hypothesized that increased CRH signaling through CRHR1 contributes to the effects of chronic corticosteroid exposure on the eCB system within the amygdala and prefrontal cortex. Male rats were exposed to 7 days of systemic corticosterone capsules, with or without concurrent exposure to a CRHR1 antagonist, after which we examined eCB content. Consistent with previous studies in the amygdala, sus...Continue Reading

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Citations

Oct 22, 2016·Biological Psychiatry·Andrés Uribe-MariñoMathias V Schmidt
Jul 27, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew N HillSachin Patel
Jul 8, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heidi C MeyerDylan G Gee
Jul 28, 2018·British Journal of Pharmacology·Martin A StichtMatthew N Hill
Jan 13, 2019·The Journal of Pharmacology and Experimental Therapeutics·Miaomiao LiHailing Yu
Aug 31, 2019·Journal of Neuroendocrinology·Alexis L FranksDonald B DeFranco
Jun 1, 2016·Cannabis and Cannabinoid Research·Michelle SextonLaurie K Mischley
May 13, 2020·Frontiers in Psychiatry·Francisco NavarreteJorge Manzanares
Aug 16, 2018·Frontiers in Neuroscience·Victoria S CavenerSachin Patel
Jan 17, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Haley A VecchiarelliMatthew N Hill
Jan 19, 2021·Alcoholism, Clinical and Experimental Research·Laura M BestChristian S Hendershot
Apr 21, 2020·Pharmacology & Therapeutics·Brenda Sbarski, Irit Akirav
Jul 24, 2018·European Journal of Pharmacology·Vincenzo Micale, Filippo Drago
Jul 26, 2017·Frontiers in Neuroendocrinology·Georgia BalsevichMatthew N Hill
Sep 2, 2021·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Mashal AhmedStefan Kloiber
Oct 6, 2018·Life Sciences·Ewa PoleszakAnna Serefko

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