Sustained glycolytic oscillations--no need for cyanide

FEMS Microbiology Letters
Allan K PoulsenLars Folke Olsen

Abstract

Using fluorescence spectroscopy we detected long trains of macroscopic oscillations in the glycolytic pathway, in whole cell suspensions of Saccharomyces cerevisiae, without addition of cyanide. Such oscillations may be induced if argon or another inert gas is bubbled through the yeast cell suspension. This supports that the synchronizing agent is a volatile compound secreted by the yeast cells, e.g. CO2 and/or acetaldehyde. Our results show that the rate of acetaldehyde removal is not a crucial parameter to the synchronization of the yeast cells. The sample cell was connected to a membrane inlet mass spectrometer (MIMS) for online determination of extracellular non-polar compounds. Oscillations in the secretion of CO2 were detected using the MIMS.

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Citations

Aug 28, 2012·BMC Systems Biology·Thomas WilliamsonLubomira Stateva
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sune DanøPreben Graae Sørensen
Dec 3, 2013·FEBS Letters·Anna-Karin GustavssonJacky L Snoep
Mar 25, 2015·Scientific Reports·Anna-Karin GustavssonMattias Goksör
Mar 9, 2005·The FEBS Journal·Matthieu JulesJean Luc Parrou
Jun 10, 2005·The FEBS Journal·Mads F MadsenPreben G Sørensen
Oct 18, 2012·The FEBS Journal·Bjørn O HaldPreben G Sørensen
Sep 14, 2013·The FEBS Journal·Tine D SchrøderLars F Olsen
Feb 16, 2011·Biophysical Journal·Jana SchützeJana Wolf
May 6, 2009·Biophysical Journal·Lars Folke OlsenAllan K Poulsen
Apr 12, 2015·Biophysical Chemistry·Bjørn Olav HaldPreben Graae Sørensen
Nov 18, 2010·Biophysical Journal·Bjørn Olav Hald, Preben G Sørensen
Dec 3, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Cecilie K YttingLars Folke Olsen
Apr 5, 2017·Physical & Occupational Therapy in Pediatrics·Kimberly D WynarczukCatherine L Gohrband
May 26, 2018·Journal of Biological Physics·Henrik Seir ThokeLuis A Bagatolli

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