Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-β-Induced Alzheimer's Disease Model.

Journal of Alzheimer's Disease : JAD
Sara L PauloSara Xapelli


The use of Alzheimer's disease (AD) models obtained by intracerebral infusion of amyloid-β (Aβ) has been increasingly reported in recent years. Nonetheless, these models may present important challenges. We have focused on canonical mechanisms of hippocampal-related neural plasticity to characterize a rat model obtained by an intracerebroventricular (icv) injection of soluble amyloid-β42 (Aβ42). Animal behavior was evaluated in the elevated plus maze, Y-Maze spontaneous or forced alternation, Morris water maze, and open field, starting 2 weeks post-Aβ42 infusion. Hippocampal neurogenesis was assessed 3 weeks after Aβ42 injection. Aβ deposition, tropomyosin receptor kinase B levels, and neuroinflammation were appraised at 3 and 14 days post-Aβ42 administration. We found that immature neuronal dendritic morphology was abnormally enhanced, but proliferation and neuronal differentiation in the dentate gyrus was conserved one month after Aβ42 injection. Surprisingly, animal behavior did not reveal changes in cognitive performance nor in locomotor and anxious-related activity. Brain-derived neurotrophic factor related-signaling was also unchanged at 3 and 14 days post-Aβ icv injection. Likewise, astrocytic and microglial markers of n...Continue Reading


Oct 1, 1991·Trends in Pharmacological Sciences·J Hardy, D Allsop
Jan 1, 1997·Annual Review of Psychology·M Gallagher, P R Rapp
Feb 1, 2000·European Archives of Psychiatry and Clinical Neuroscience·H Förstl, A Kurz
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
May 10, 2006·Genes, Brain, and Behavior·N SousaC T Wotjak
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
Jun 22, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laure VerretClaire Rampon
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
Aug 9, 2008·The Journal of Pharmacology and Experimental Therapeutics·Dorothee AbramowskiMatthias Staufenbiel
Dec 3, 2008·Neuroimmunomodulation·Nathan L Sparkman, Rodney W Johnson
Dec 18, 2008·Expert Review of Neurotherapeutics·Carl A Gold, Andrew E Budson
Mar 26, 2009·Learning & Memory·Ana Garcia-Osta, Cristina M Alberini
Apr 24, 2009·Acta Neuropathologica·Henning BreyhanThomas A Bayer
Aug 13, 2009·International Journal of Geriatric Psychiatry·J D Huntley, R J Howard
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paula M CanasRodrigo A Cunha
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·M Paul Murphy, Harry LeVine
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Claudia BalducciGianluigi Forloni
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie CrewsEliezer Masliah
Oct 23, 2010·Methods in Molecular Biology·W Blaine StineMary Jo LaDu
Mar 15, 2011·The European Journal of Neuroscience·Beate WinnerFred H Gage
Jun 23, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mazen A KheirbekRené Hen
Jul 5, 2012·Cognitive, Affective & Behavioral Neuroscience·Amber R SalomonsFrauke Ohl
Jan 5, 2013·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Meige ZhengGuoying Li
Nov 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael J Yetman, Joanna L Jankowsky
Feb 5, 2014·Neurobiology of Aging·Zareen AmtulDavid F Cechetto
Apr 1, 2014·Oxidative Medicine and Cellular Longevity·Paul Carrillo-MoraLaura Colín-Barenque
May 27, 2014·Cerebral Cortex·André Jerónimo-SantosMaria José Diógenes
Sep 11, 2014·Annals of Neurology·Benjamin T KressMaiken Nedergaard
Feb 26, 2015·Pharmacological Reports : PR·Anil Kumar Ekavali
May 1, 2015·Expert Opinion on Drug Discovery·Daniela PuzzoOttavio Arancio

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