Sustained impact of nosocomial-acquired spontaneous bacterial peritonitis in different stages of decompensated liver cirrhosis

PloS One
Markus KimmannBenjamin Maasoumy

Abstract

Bacterial infections, in particular a spontaneous bacterial peritonitis (SBP), are a major threat in patients with liver cirrhosis. Recently, it has been shown that the impact on mortality might be underestimated by established risk-scores. Onset of infection was suggested to define a distinct stage of cirrhosis. However, it remains unclear whether all stages of decompensated cirrhosis are equally affected. Moreover, if there is such a distinct stage, it must be determined whether it is reversible after the infection has resolved. In this study we aimed to further analyze the impact of a current as well as a resolved SBP in different stages of decompensated liver cirrhosis. A number of 579 patients with liver cirrhosis and ascites were included. MELD-score was used to determine the stage of liver disease. Low (<15), intermediate (15-25) and high (>25) MELD-groups were compared. Patients were followed up for 90 days. Primary endpoint was overall mortality. Statistical analyses were performed using the log-rank test, Cox regression and competing risk analysis. Mortality was significantly higher in patients with nosocomial-acquired SBP (nSBP) compared to patients without SBP (p<0.001;HR = 2.05). However, the most prominent differe...Continue Reading

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Citations

Jun 10, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Luke TownsendGregory S Sayuk
Sep 22, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Bianca MagroFilomena Conti
Sep 30, 2021·Hepatology Communications·Lena StockhoffBenjamin Maasoumy

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
GraphPad Prism
Excel
Metavir
FibroScan
R
app GUI
GraphPad

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