PMID: 640299Apr 1, 1978

Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas

Diabetologia
J MirouzeA Orsetti

Abstract

Remission of diabetes was attempted in 12 recent acute onset ketosis-prone juvenile diabetes after short term (5 +/- 1 days) but excellent blood glucose control by the external artificial beta-cell. The comparison group comrised patients undergoing traditional treatment (n = 28). Nine (75%) persistent (over 3-14 months of duration) although partial (oral drugs required) remissions were obtained in the former group as compared to 3 (11%) in the latter group (p less than 0.05). Cases which showed remissions after insulin infusion had a plasma insulin response to IV glucagon still present before insulin infusion, and a daily urinary C-peptide excretion significantly enhanced after (p less than 0.01). Urinary C-peptide/blood glucose remained improved during the remission period. Thus, early effective treatment by means of the artificial pancreas may break the vicious circle hyperglycaemia-insulin depletion-hyperglycaemia and lead to frequent and sustained remissions of juvenile diabetes.

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Feb 26, 1977·Lancet·R R Holman, R C Turner
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Related Concepts

Glucagon (rDNA)
Remission, Spontaneous
Benign Tumor of Pancreas
C-Peptide
Acute Disease
Glucagon
Insulin C-peptide Measurement
Cancer Remission
Glucagon Measurement
Body Excretions

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