Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice

Frontiers in Physiology
Mélany PierardAlexandre Legrand

Abstract

Introduction: Hypoxemia is a critical component of several respiratory diseases and is known to be involved in the processes underlying co-morbidities associated to such disorders, notably at the cardiovascular level. Circulating level of Adiponectin (Ad), known as a metabolic regulator and cardio-protective hormone was previously suggested to be reduced by hypoxia but consequences of such variation are unclear. The evaluation of the specific effect of hypoxemia on Ad forms and receptors could improve the understanding of the involvement of Ad axis in hypoxemia-related diseases. Methods: Ad-pathway components were investigated in a murine model of sustained intermittent hypoxemia (FiO2 10%, 8 h/day, 35 days). Results: Sustained intermittent hypoxemia (SIH) induced a redistribution of Ad multimers in favor of HMW forms, without change in total plasmatic level. Mice submitted to hypoxia also exhibited tissue-specific modification of adiporeceptor (AdipoR) protein level without mRNA expression change. A decreased AdipoR2 abundance was observed in skeletal muscle and heart whereas AdipoR1 level was only reduced in muscle. No change was observed in liver regarding AdipoR. Lipid profile was unchanged but glucose tolerance increased i...Continue Reading

References

Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D M StrokaD Candinas
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amanda W WyattGiovanni E Mann
May 27, 2004·The American Journal of Pathology·Carine Michiels
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
May 30, 2006·The Journal of Endocrinology·Hu HuangRyuichi Ajisaka
Jul 11, 2006·The Journal of Clinical Investigation·Takashi KadowakiKazuyuki Tobe
Mar 16, 2007·American Journal of Physiology. Endocrinology and Metabolism·Kerry L MullenDavid J Dyck
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vladimir SavranskyVsevolod Y Polotsky
Mar 31, 2007·Diabetes·Naomi HosogaiIichiro Shimomura
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jianping YeQing He
May 1, 2008·Endocrine Journal·Wataru YanoTakashi Kadowaki
Jun 20, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·U J MagalangN L Parinandi
Jul 22, 2008·Metabolism: Clinical and Experimental·Joumana T ChaibanSami T Azar
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kerry L MullenDavid J Dyck
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T Yamauchi, T Kadowaki
May 7, 2010·American Journal of Physiology. Renal Physiology·Volker H Haase
Oct 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J L GamboaFrancisco H Andrade
Jun 11, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Brian D KentWalter T McNicholas
Jan 12, 2012·The International Journal of Biochemistry & Cell Biology·Aurora DanieleAndrea Bianco
Jan 25, 2012·Respiration; International Review of Thoracic Diseases·A J R van GestelM Kohler
Mar 1, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Claudio Tantucci, Denise Modina
Mar 1, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wei ZhouBaoyuan Chen
Apr 27, 2012·International Journal of Hematology·Nobuhito Goda, Mai Kanai
Sep 29, 2012·Vitamins and Hormones·Yaniv LustigHannah Kanety
Dec 21, 2012·The Journal of Biological Chemistry·Changtao JiangFrank J Gonzalez
Jan 19, 2013·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerVsevolod Y Polotsky
Jan 29, 2013·Cell Metabolism·Toshimasa Yamauchi, Takashi Kadowaki
Feb 7, 2013·Journal of Lipid Research·Qiaoling YaoVsevolod Y Polotsky
Mar 30, 2013·Journal of Applied Physiology·Bram van den BorstHarry R Gosker
Apr 9, 2013·PloS One·Kamil J ChodzyńskiAlexandre Legrand
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Toshimasa YamauchiTakashi Kadowaki
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Meilian Liu, Feng Liu
Mar 13, 2014·American Journal of Physiology. Endocrinology and Metabolism·Hidemitsu SakagamiMasakazu Haneda
Sep 7, 2014·G3 : Genes - Genomes - Genetics·Sherin BakhashabJolanta U Weaver
Sep 27, 2014·The Annals of Thoracic Surgery·Robina MatyalFeroze Mahmood
Jan 7, 2015·Chest·Naresh A DewanVirend K Somers
Jan 31, 2015·Molecular Medicine Reports·Hechun DuTao Zhang
Sep 22, 2015·Current Opinion in Pulmonary Medicine·Aaron M Pierce, Lee K Brown
May 31, 2016·Journal of Cachexia, Sarcopenia and Muscle·Tahnee SenteChristiaan J Vrints

❮ Previous
Next ❯

Citations

Mar 9, 2021·Frontiers in Endocrinology·Florentina DuicăDragoş Creţoiu
Jun 22, 2021·Journal of Sleep Research·Isaac AlmendrosTarja Saaresranta

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Image J

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.