Sustained liver regeneration after portal vein embolization --a human molecular pilot study

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Falk RauchfussUtz Settmacher

Abstract

Portal vein embolization is a treatment option to achieve a sufficient future remnant liver volume for patients with central liver tumours requiring an extended resection with an extensive parenchymal loss. However, molecular mechanisms of this intervention are up to now poorly understood. The objective of this prospective pilot study was the characterization of molecular events leading to late hypertrophy of the non-embolized liver tissue in the human liver. Liver tissue of ten patients was collected before and intraoperatively more than one month after embolization. Investigation of molecular features was performed by pangenomic chips, polymerase chain reaction, immunostaining of proliferation marker Ki-67 and immunofluorescence measurements. Significantly elevated genes hint towards angiogenesis and signalling by insulin-like growth factor and associated binding proteins. Increased transcript levels of activator protein 1 complex members like c-jun were reflecting potential molecular events of liver growth after embolization. Immunofluorescence data confirmed a predominant upregulation of β-catenin and c-jun (p<0.1) supported by Ki-67 (p<0.05) in the non-embolized liver. In silico analysis of transcriptomic dysplasia and hep...Continue Reading

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Citations

Dec 10, 2013·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·U SettmacherF Rauchfuss
Sep 17, 2013·World Journal of Gastroenterology : WJG·Koji HamasakiTamotsu Kuroki
Aug 25, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Bin LiXiaoqing Jiang
Aug 2, 2017·Clinical & Experimental Metastasis·Eve SimoneauPeter Metrakos

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