Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injury

Brain Research Bulletin
E CianiAndrea Contestabile

Abstract

Brain nitric oxide (NO) can be a mediator of physiological and neuroprotective actions and an effector of neural damage. The effectiveness of acute or chronic inhibition of NO production in in vivo experiments of neurotoxicity/neuroprotection is controversial. We report here on the effects of a chronic, sustained inhibition of nitric oxide synthase (NOS) on the neurodegenerative damage caused by three different excitotoxic lesions. The damage caused by intrastriatal injection of ibotenic or kainic acid was aggravated in rats subjected to chronic NOS inhibition. On the contrary, the drop of cortical cholinergic input consequent to ibotenic acid-mediated degeneration of basal forebrain neurons was not altered by chronic NOS inhibition. The worsening of the damage was not related to any overt differential sensitivity to excitotoxicity of NOS-containing striatal neurons under conditions of NOS inhibition. These results suggest that, contrary to what has been often reported for short-term, mild inhibition of NO production, chronic and sustained NOS inhibition may exacerbate neuropathology. Thus, long-lasting shortage of NO may be detrimental when neuroprotective mechanisms related to the physiological action of this free radical are...Continue Reading

References

Mar 24, 1992·Biochemistry·T G Traylor, V S Sharma
Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YamamotoD J Reis
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Nov 26, 1993·Brain Research·H FujisawaJ McCulloch
Jan 1, 1995·Annual Review of Physiology·J Garthwaite, C L Boulton
Jan 1, 1995·Annual Review of Physiology·S S Gross, M S Wolin
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Y GlobusM D Ginsberg
Jan 1, 1995·Zhonghua nei ke za zhi·Y Zhu
Aug 12, 1993·Nature·S H Snyder
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F ZhangC Iadecola
Jun 1, 1996·Journal of Chemical Neuroanatomy·V L Dawson, T M Dawson
Aug 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·P L Huang, M C Fishman
Nov 22, 1996·Neuroscience Letters·B E KalischR J Boegman
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C MontécotE Pinard
Mar 1, 1997·Trends in Neurosciences·C Iadecola
May 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H HaraM A Moskowitz
Jun 1, 1997·Stroke; a Journal of Cerebral Circulation·A F SamdaniV L Dawson
Jul 1, 1997·Molecular Psychiatry·H Y YunT M Dawson
Apr 1, 1997·Nitric Oxide : Biology and Chemistry·K D KrönckeV Kolb-Bachofen
Nov 6, 1998·Neurochemical Research·F Pérez-SeverianoC Ríos

❮ Previous
Next ❯

Citations

Dec 21, 2006·Toxicology and Applied Pharmacology·Jing LiuCarey Pope
Aug 18, 2004·Neurochemistry International·Antonio Contestabile, Elisabetta Ciani
Sep 6, 2005·Brain Research·Emiliano Peña-AltamiraAntonio Contestabile
May 16, 2003·Journal of Neuroscience Research·Katarina SandgrenEva Ekblad
Aug 29, 2013·TheScientificWorldJournal·Moamena El-MatboulyRifat Latifi
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jong-Seon ByunWanjoo Chun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Related Papers

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Jong-Seon ByunWanjoo Chun
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Ahmed O Abdel-ZaherSafa Y Salim
© 2021 Meta ULC. All rights reserved