Sustained neurological recovery induced by resveratrol is associated with angioneurogenesis rather than neuroprotection after focal cerebral ischemia

Neurobiology of Disease
Dirk M HermannThorsten R Doeppner

Abstract

According to the French paradox, red wine consumption reduces the incidence of vascular diseases even in the presence of highly saturated fatty acid intake. This phenomenon is widely attributed to the phytoalexin resveratrol, a red wine ingredient. Experimental studies suggesting that resveratrol has neuroprotective properties mostly used prophylactic delivery strategies associated with short observation periods. These studies did not allow conclusions to be made about resveratrol's therapeutic efficacy post-stroke. Herein, we systematically analyzed effects of prophylactic, acute and post-acute delivery of resveratrol (50mg/kg) on neurological recovery, tissue survival, and angioneurogenesis after focal cerebral ischemia induced by intraluminal middle cerebral artery occlusion in mice. Over an observation period of four weeks, only prolonged post-acute resveratrol delivery induced sustained neurological recovery as assessed by rota rod, tight rope and corner turn tests. Although prophylactic and acute resveratrol delivery reduced infarct volume and enhanced blood-brain-barrier integrity at 2 days post-ischemia by elevating resveratrol's downstream signal sirtuin-1, increasing cell survival signals (phosphorylated Akt, heme oxy...Continue Reading

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Citations

Jul 5, 2016·Biochimica Et Biophysica Acta·Bruna BellaverAndré Quincozes-Santos
Jan 31, 2017·International Journal of Molecular Sciences·Olatz ArteagaEnrique Hilario
Feb 15, 2017·Nutritional Neuroscience·Narayana Pineda-RamírezPenélope Aguilera
Nov 1, 2017·Frontiers in Molecular Neuroscience·Juliane SünwoldtPhilipp Mergenthaler
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Fangzhou Jiao, Zuojiong Gong
Sep 5, 2019·Nutrients·Beatriz Martínez-PovedaAna R Quesada
Jul 8, 2017·Antioxidants & Redox Signaling·Nathalie KhouryMiguel A Perez-Pinzon
Apr 8, 2021·Neurorehabilitation and Neural Repair·Matthew W McDonaldDale Corbett
May 28, 2021·Toxicology and Applied Pharmacology·Jinghan LiYonggang Gao
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Yuan ZhouXiang Fan

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