DOI: 10.1101/492082Dec 10, 2018Paper

Sustained oscillations of epithelial cell sheets

BioRxiv : the Preprint Server for Biology
Gregoire PeyretBenoit Ladoux


Morphological changes during development, tissue repair, and disease largely rely on coordinated cell movements and are controlled by the tissue environment. Epithelial cell sheets are often subjected to large scale deformation during tissue formation. The active mechanical environment in which epithelial cells operate have the ability to promote collective oscillations, but how these cellular movements are generated and relate to collective migration remains unclear. Here, combining in vitro experiments and computational modelling we describe a novel mode of collective oscillations in confined epithelial tissues where the oscillatory motion is the dominant contribution to the cellular movements. We show that epithelial cells exhibit large-scale coherent oscillations when constrained within micro-patterns of varying shapes and sizes, and that their period and amplitude are set by the smallest confinement dimension. Using molecular perturbations, we then demonstrate that force transmission at cell-cell junctions and its coupling to cell polarity are pivotal for the generation of these collective movements. We find that the resulting tissue deformations are sufficient to trigger mechanotransduction within cells, potentially affec...Continue Reading

Related Concepts

Cell Motility
Epithelial Cells
Disease Transmission
Brain Waves
Research Study
Mechanotransduction, Cellular

Related Feeds

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
S R K VedulaBenoit Ladoux
Integrative Biology : Quantitative Biosciences From Nano to Macro
Kevin DoxzenChwee Teck Lim
Current Opinion in Cell Biology
Minerva Bosch-Fortea, Fernando Martín-Belmonte
© 2021 Meta ULC. All rights reserved