Sustained preinspiratory cortical potentials during prolonged inspiratory threshold loading in humans

Journal of Applied Physiology
L TremoureuxT Similowski

Abstract

Humans can program and control movements, including breathing-related movements. On the electroencephalogram (EEG), this preparation is accompanied by a low-amplitude negativity starting approximately 2.5 s before inspiration that is best known as a Bereitschaftspotential (BP). The presence of BPs has been described during the compensation of mechanical inspiratory loading, thus identifying a cortical involvement in the corresponding ventilatory behavior. The pathophysiological interpretation of this cortical involvement depends on its transient or enduring nature. This study addressed this issue by looking for BPs during sustained inspiratory loading (1 h). Nine healthy male volunteers were studied during unloaded quiet breathing and inspiratory threshold loading (with unloaded expiration). Analyses of EEG signal and ventilatory variables were used to compare beginning and end of sessions. Inspiratory threshold loading caused ventilatory modifications that persisted, unchanged, for an hour. The presence of a BP at the beginning and end of a session was the most frequent occurrence (6 of 9 cases with a 17-cmH2O threshold load; 8 of 9 cases with a 23-cmH2O load). These observations support the hypothesis that the cerebral cortex...Continue Reading

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Citations

Oct 20, 2012·Respiratory Physiology & Neurobiology·Judita JeranJanez Zidar
Apr 23, 2011·Respiratory Physiology & Neurobiology·Kylie Hill, Peter Eastwood
May 10, 2011·Revue des maladies respiratoires·T Perez, N Roche
Mar 8, 2013·Depression and Anxiety·Martin P Paulus
Apr 22, 2014·Respiratory Physiology & Neurobiology·Franco LaghiMartin J Tobin
Mar 2, 2019·Experimental Physiology·Claire LaunoisStefania Redolfi
Apr 9, 2019·The European Respiratory Journal·Pierantonio LavenezianaSamuel Verges
Jan 1, 2013·Brain Sciences·Rolando Grave de PeraltaStephen Perrig
Feb 11, 2015·Journal of Applied Physiology·Elise MorawiecThomas Similowski
Nov 12, 2018·Journal of the Royal Army Medical Corps·Marie-Cécile NieratT Similowski
Dec 8, 2019·American Journal of Respiratory and Critical Care Medicine·Christophe RaultXavier Drouot
Jul 17, 2020·Journal of Applied Physiology·Franco LaghiMartin J Tobin
Jun 15, 2018·Frontiers in Physiology·Anna L HudsonThomas Similowski

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