Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.

The Journal of Clinical Endocrinology and Metabolism
Mandeep BajajRalph A DeFronzo

Abstract

To investigate the effect of a sustained (7-d) decrease in plasma free fatty acid (FFA) concentration in individuals genetically predisposed to develop type 2 diabetes mellitus (T2DM), we studied the effect of acipimox, a potent inhibitor of lipolysis, on insulin action and adipocytokine concentrations in eight normal glucose-tolerant subjects (aged 40 +/- 4 yr, body mass index 26.5 +/- 0.8 kg/m(2)) with at least two first-degree relatives with T2DM. Subjects received an oral glucose tolerance test (OGTT) and 120 min euglycemic insulin clamp (80 mU/m(2).min) with 3-[(3)H] glucose to quantitate rates of insulin-mediated whole-body glucose disposal (Rd) and endogenous (primarily hepatic) glucose production (EGP) before and after acipimox, 250 mg every 6 h for 7 d. Acipimox significantly reduced fasting plasma FFA (515 +/- 64 to 285 +/- 58 microm, P < 0.05) and mean plasma FFA during the OGTT (263 +/- 32 to 151 +/- 25 microm, P < 0.05); insulin-mediated suppression of plasma FFA concentration during the insulin clamp also was enhanced (162 +/- 18 to 120 +/- 15 microm, P < 0.10). Following acipimox, fasting plasma glucose (5.1 +/- 0.1 vs. 5.2 +/- 0.1 mm) did not change, whereas mean plasma glucose during the OGTT decreased (7.6 +/-...Continue Reading

Citations

Jun 9, 2006·Cardiovascular Drugs and Therapy·Manuel González-OrtizMaria Guadalupe Ramos-Zavala
Oct 12, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Christine AhlströmJohan Gabrielsson
May 13, 2010·The Journal of Biological Chemistry·Guo LiNaiming Zhou
Sep 22, 2007·Critical Care Medicine·Melanie G CreeRobert R Wolfe
Jul 2, 2005·Current Opinion in Lipidology·Keith N FraynFredrik Karpe
Jan 24, 2007·Acta Pharmacologica Sinica·Nan GuXi-rong Guo
Mar 28, 2012·Journal of Diabetes Investigation·Shinji IchimoriEiichi Araki
May 7, 2010·Journal of Biomedicine & Biotechnology·Muhammad A Abdul-Ghani, Ralph A DeFronzo
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Colleen HadiganSteven Grinspoon
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideki NishimuraKuniaki Otsuka
Dec 24, 2013·Nature Chemical Biology·Eduardo DominguezEnrique Saez
Jun 7, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Melanie G CreeRobert R Wolfe
May 16, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lin-Chau ChangWei-Shiung Yang
Aug 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·J P H Wilding
Oct 2, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·George R BeckGuillermo E Umpierrez
Jun 30, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Etienne PouteauMichel Krempf
Nov 7, 2015·Biochimie·Pauline MorignyDominique Langin
Nov 3, 2012·Experimental Diabetes Research·Yong ZhongShisen Jiang
Mar 10, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P J ManningA R Ryalls
Feb 2, 2013·Diabetes Research and Clinical Practice·Tetsuji TsunodaIchiro Michishita
Aug 1, 2010·Current Therapeutic Research, Clinical and Experimental·Tsuyoshi NozueIchiro Mizuguchi
Feb 16, 2010·Biochimica Et Biophysica Acta·Pawel DobrzynAgnieszka Dobrzyn
Nov 13, 2009·Diabetes Care·Ralph A DeFronzo, Devjit Tripathy
Aug 27, 2005·Diabetes Care·John M Miles, Michael D Jensen
Apr 1, 2008·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Enrique González-SarmientoE Inmaculada Fernández-Galante
Sep 22, 2017·Journal of Nephrology·Giacomo GaribottoDaniela Verzola
May 29, 2008·American Journal of Physiology. Endocrinology and Metabolism·Sara RigazioPatricia Iozzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.