Sustained-release amorphous solid dispersions

Drug Delivery and Translational Research
Julien Maincent, Robert O Williams

Abstract

The use of amorphous solid dispersions (ASD) to overcome poor drug solubility has gained interest in the pharmaceutical industry over the past decade. ASDs are challenging to formulate because they are thermodynamically unstable, and the dispersed drugs tend to recrystallize. Until now, most research on ASDs has focused on immediate-release formulations, supersaturation, and stability; only a few studies have recently reported on the manufacturing of sustained-release ASDs. Sustained-release ASDs can minimize the frequency of administration and prevent high concentrations that can lead to toxicity. Sustained-release ASDs can also decrease the reprecipitation rate in the medium, which can lead to increased bioavailability. However, sustained-release ASDs also pose some significant challenges, such as intramatrix recrystallization, inhibition of drug release as a result of drug-polymer gelling, and low supersaturation due to a slow dissolution rate. This review details the challenges and the formulation approaches that have been investigated to manufacture sustained-release ASDs. In particular, the advantages and drawbacks of hydrophilic polymers, hydrophobic polymers, and lipid-based systems are discussed.

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Citations

Nov 7, 2019·Pharmaceutical Development and Technology·Xin-Yi TeohSiok-Yee Chan
Jul 16, 2020·Advanced Pharmaceutical Bulletin·Avinash Ramrao Tekade, Jyoti Narayan Yadav
Dec 28, 2018·Pharmaceutics·Laura Modica de MohacBahijja Tolulope Raimi-Abraham
Nov 5, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Urvi H GalaRobert O Williams

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