Sustained release of herbal drugs using biodegradable scaffold for faster wound healing and better patient compliance

Nanomedicine : Nanotechnology, Biology, and Medicine
Arpan BiswasPralay Maiti

Abstract

Electrospun scaffold has been developed using biodegradable polymer and age old herbal drug for efficient wound healing patch with much better patient compliance. Positively charged smaller particle size (40 nm) of the drug has been prepared for greater penetration through epidermal barrier to enhance the wound healing activity of drug. Controlled drug release has been understood in terms of interactions between the components through spectroscopic techniques and calorimetric studies. In-vivo study using albino rats shows better wound healing efficiency of scaffold in terms of higher wound area contraction, minimum inflammation, faster epithelialization and vascularization. Cellular studies also endorse the scaffold as better biomaterial. Clinical studies also demonstrate fast healing of different type of wounds in presence of all three wound dressing materials with histological evidences. The complete biodegradation of the patch confirms its green nature of the developed patch.

Citations

Oct 23, 2019·Signal Transduction and Targeted Therapy·Akhand Pratap SinghPralay Maiti
Jan 31, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Vinu VijayanManikantan Syamala Kiran
Feb 13, 2021·International Journal of Molecular Sciences·Luis Castillo-HenríquezJosé Vega-Baudrit
Aug 30, 2020·Signal Transduction and Targeted Therapy·Akhand Pratap SinghPralay Maiti
Apr 10, 2021·APL Bioengineering·Muhammad Anwaar NazeerSeda Kizilel
Jul 24, 2020·Biomacromolecules·Bhingaradiya NutanSuresh K Jewrajka
May 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Arpan BiswasPralay Maiti

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