PMID: 7025336Apr 1, 1981Paper

Sustained release oral aminophylline in patients with airflow obstruction

Thorax
A P GreeningN B Pride

Abstract

Twenty-four patients with reversible airflow obstruction under suboptimal control on conventional therapy entered a double-blind placebo-controlled trial of additional oral sustained release aminophylline. Assessment was by diary cards, twice daily PEFR, and weekly FEV1. Nineteen patients completed the trial satisfactorily. Eleven were improved subjectively by addition of aminophylline. The mean PEFR for all 19 patients rose from 232 1 min-1 SEM +/- 5, to 247 1 min-1 SEM +/- 4 (p less than 0.0001); nine individuals showed a statistically significant improvement in mean PEFR and 10 showed an improvement of greater than 200 ml in their FEV1. Improvement in PEFR on aminophylline was not at the expense of benefit from inhaled salbutamol. Unwanted effects of nausea, headache, and abdominal discomfort were recorded by 12 of the 24 patients entering the trial. Seventeen of the 19 patients completing the trial had plasma theophylline levels in the accepted therapeutic range of 10-20 mg 1(-1). The drug doses required to achieve these levels varied from 8.6-30.8 mg kg-1 24 hr-1 in the patients with no clinical or biochemical evidence of liver disease. Oral aminophylline can improve control of airflow obstruction in patients with moderate...Continue Reading

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Citations

May 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P D Slinger
Mar 12, 1983·British Medical Journal·D C Flenley
Mar 1, 1984·Postgraduate Medical Journal·M R Hetzel
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K F Chung
Jul 1, 1986·British Journal of Diseases of the Chest·I D JohnstonM R Hetzel
Dec 20, 1985·The American Journal of Medicine·E R McFadden
Jun 1, 1996·Human & Experimental Toxicology·N A Minton, J A Henry
Jan 10, 2003·The Cochrane Database of Systematic Reviews·F S RamS Cendon
Mar 1, 1984·Journal of Clinical and Hospital Pharmacy·I D Green
Jan 2, 1988·British Medical Journal·K F Chung, P J Barnes
Dec 1, 1990·Alimentary Pharmacology & Therapeutics·M LazzaroniG Bianchi Porro

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