Sustained Release Strategy Designed for Lixisenatide Delivery to Synchronously Treat Diabetes and Associated Complications

ACS Applied Materials & Interfaces
Yaping ZhuangJiandong Ding

Abstract

Diabetes and its complications have become a global challenge of public health. Herein, we aimed to develop a long-acting delivery system of lixisenatide (Lixi), a glucose-dependent antidiabetic peptide, based on an injectable hydrogel for the synchronous treatment of type 2 diabetes mellitus (T2DM) and associated complications. Two triblock copolymers, poly(ε-caprolactone-co-glycolic acid)-poly(ethylene glycol)-poly(ε-caprolactone-co-glycolic acid) and poly(d,l-lactic acid-co-glycolic acid)-poly(ethylene glycol)-poly(d,l-lactic acid-co-glycolic acid) possessing temperature-induced sol-gel transitions, were synthesized by us. Compared to the two single-component hydrogels, their 1/1 mixture hydrogel not only maintained the temperature-induced gelation but also exhibited a steadier degradation profile in vivo. Both in vitro and in vivo release studies demonstrated that the mixture hydrogel provided the sustained release of Lixi for up to 9 days, which was attributed to balanced electrostatic interactions between the positive charges in the peptide and the negative charges in the polymer carrier. The hypoglycemic efficacy of Lixi delivered from the mixture hydrogel after a single subcutaneous injection into diabetic db/db mice wa...Continue Reading

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Citations

Jan 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yu ChenJiandong Ding
Jan 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yanan WangZhiyu He
Feb 26, 2021·International Journal of Nanomedicine·Chen LiKeke Wang
Mar 11, 2021·ACS Applied Materials & Interfaces·Ling HuangXiaolei Wang
Mar 22, 2021·European Journal of Medicinal Chemistry·Yupeng FuPeng Yu
Apr 16, 2021·Acta Biomaterialia·Jiayue ShiJiandong Ding
May 8, 2021·Biomacromolecules·Tianqi NieZhiyu He

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