Sustained remission after corticosteroid therapy for type 1 autoimmune hepatitis: a retrospective analysis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Albert J CzajaH A Carpenter

Abstract

Autoimmune hepatitis commonly relapses after corticosteroid therapy, and long-term management strategies have been proposed based on the premise that repeated relapses after drug withdrawal are inevitable. Our goal was to determine the frequency that remission can be sustained after its induction and termination of therapy. A total of 107 patients who had entered remission on conventional regimens were assessed for sustained remission after initial treatment and after relapse and re-treatment. Re-treatment strategies included conventional regimens and long-term maintenance schedules. Twenty-two patients (21%) achieved a sustained remission after initial treatment, and 24 of 85 patients who relapsed and were re-treated (28%) had a similar outcome. The probability of a sustained remission was 47% after 10 years of follow-up. Patients who sustained remission after initial therapy were distinguished only by a lower serum gamma-globulin level at entry. Conventional re-treatment schedules after relapse were able to induce a sustained remission more commonly then long-term maintenance schedules (59% vs. 12%, P =.00002). In conclusion, patients who respond to initial corticosteroid therapy can achieve a sustained remission after treatm...Continue Reading

References

Jan 1, 1991·Autoimmunity·E Talor, N R Rose
Jun 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J Czaja
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J StellonR Williams
Sep 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E HegartyR Williams
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaH F Taswell
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Oct 12, 1995·The New England Journal of Medicine·P J JohnsonR Williams
Nov 1, 1993·Gastroenterology·A J CzajaS B Moore
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J Johnson, I G McFarlane
Mar 1, 1996·Gastroenterology·S K RobertsA J Czaja
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaF B Bianchi
Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaR Williams
Aug 1, 1997·Digestive Diseases and Sciences·A J CzajaF B Bianchi
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaK D Lindor

❮ Previous
Next ❯

Citations

Apr 29, 2006·Advances in Therapy·Keiichiro YoneyamaMichio Inawari
Nov 30, 2005·Current Treatment Options in Gastroenterology·Joseph Ahn, Steven L Flamm
Mar 20, 2004·Journal of Hepatology·Albert J Czaja, Herschel A Carpenter
Apr 4, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Aldo J Montano Loza, Albert J Czaja
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Albert J CzajaUNKNOWN American Association for the Study of Liver Disease
Sep 8, 2005·Journal of Clinical Gastroenterology·Albert J Czaja, Herschel A Carpenter
Apr 1, 2008·Journal of Gastroenterology and Hepatology·Suk SeoMyron J Tong
May 20, 2009·World Journal of Gastroenterology : WJG·Albert J Czaja, Yusuf Bayraktar
Feb 25, 2010·World Journal of Gastroenterology : WJG·Albert J Czaja
Jan 19, 2012·World Journal of Gastroenterology : WJG·Hai-Xia WangJin Gao
Dec 3, 2014·Clinics in Liver Disease·Albert J Czaja
May 29, 2004·European Journal of Gastroenterology & Hepatology·Liana GheorgheCristina Toader
Jan 23, 2010·Digestive Diseases and Sciences·Yoshiyuki SuzukiHiromitsu Kumada
Apr 30, 2010·Digestive Diseases and Sciences·Albert J Czaja
Feb 18, 2011·Digestive Diseases and Sciences·Albert J Czaja
Apr 6, 2012·Digestive Diseases and Sciences·Albert J Czaja
Jan 12, 2013·Digestive Diseases and Sciences·Albert J Czaja
Jun 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·Giorgina Mieli-VerganiKaren F Murray
Aug 23, 2008·Journal of Clinical Gastroenterology·Aldo J Montano-LozaAlbert J Czaja
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Aug 4, 2010·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Jul 26, 2011·Expert Review of Gastroenterology & Hepatology·Hind I Fallatah, Hisham O Akbar
May 4, 2013·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Jun 3, 2009·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
May 9, 2008·Expert Opinion on Drug Safety·Albert J Czaja
Mar 15, 2011·Gastroenterology·Barbara HoeroldtDermot Gleeson
Aug 3, 2010·La Revue de médecine interne·C Corpechot, O Chazouillères
May 11, 2010·Gastroenterology·Albert J Czaja, Michael P Manns
May 12, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J BarrioM J Rivero
May 16, 2009·Clinics in Liver Disease·Karen L Krok, Santiago J Munoz
Jul 7, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Srinivas SeelaJames L Boyer
Jul 7, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Patrick TanPaul Adams
Mar 26, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Albert J Czaja, Herschel A Carpenter
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Albert J Czaja
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Albert J Czaja, Herschel A Carpenter
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Aldo J Montano-LozaAlbert J Czaja
Apr 4, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Aldo J Montano-LozaAlbert J Czaja
Jun 30, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Junko YokokawaHiromasa Ohira
May 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Woo-Yong LeePaul Kubes
Jul 3, 2013·Alimentary Pharmacology & Therapeutics·A J Czaja
Mar 19, 2014·Alimentary Pharmacology & Therapeutics·A J Czaja
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Junko YokokawaHiromasa Ohira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Albert J CzajaH F Taswell
Liver International : Official Journal of the International Association for the Study of the Liver
Aldo J Montano-LozaAlbert J Czaja
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Albert J CzajaAmerican Association for the Study of Liver Disease
Clinics in Liver Disease
John M Vierling, Patricia A Flores
© 2022 Meta ULC. All rights reserved