Sustained response of a clivus chordoma to erlotinib after imatinib failure

Case Reports in Oncology
Aline HouessinonBruno Chauffert

Abstract

Chordoma is a rare malignant axial tumour that develops from embryonic remnants of the notochord. Surgery and irradiation are the standard initial treatment. However, local recurrence is frequent and cytotoxic chemotherapy is inefficient. Transient activity of imatinib, a platelet-derived growth factor receptor inhibitor, was described in a phase II study. Activity of epidermal growth factor receptor (EGFR) inhibitors (erlotinib, gefitinib) has also been shown in a few recent case reports. We describe a 68-year-old female in whom clivus chordoma recurred after surgery and radiotherapy. The tumour progressed despite imatinib treatment. A partial and sustained response (28+ months) was obtained using erlotinib, an EGFR inhibitor. Erlotinib should be evaluated in a prospective trial investigating new potential therapies against recurrent chordoma.

Citations

Apr 23, 2016·The Journal of Pathology·Susanne ScheiplAdrienne M Flanagan
Feb 19, 2019·Frontiers in Oncology·Tong MengLiming Cheng
Oct 17, 2018·Cold Spring Harbor Molecular Case Studies·Winnie S LiangAndrew S Little
Dec 15, 2017·Molecular Cancer Therapeutics·Paola MagnaghiAntonella Isacchi
Dec 15, 2020·Clinical Sarcoma Research·Saurav VermaS T Arun Raj
Apr 4, 2021·Journal of Clinical Medicine·Sean M BarberZiya L Gokaslan
Oct 23, 2020·Clinical Neurology and Neurosurgery·Klaus ZweckbergerAndreas Unterberg
Jun 15, 2021·The Journal of Pathology·Tianna ZhaoGary L Gallia

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Methods Mentioned

BETA
surgical resection
xenograft

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