Sustained sensorimotor impairments after endothelin-1 induced focal cerebral ischemia (stroke) in aged rats.

Experimental Neurology
Sara SolemanLawrence Moon

Abstract

Despite recent advances, stroke remains a leading cause of neurological disability with the vast majority of victims being the elderly, who exhibit more severe neurological deficits and a reduced capacity to recover from these disabilities in comparison to young stroke survivors. The objective of the present study was to develop a model of focal ischemic stroke in aged rats using endothelin-1 (ET-1) to produce low mortality rates as well as reliable, robust sensorimotor deficits that resemble functional impairments associated with stroke in humans. Here, we studied the functional and histological outcome following unilateral ET-1 infusions into the sensorimotor cortex of aged rats (20-23 months old). This procedure resulted in low mortality rates (13.3%) and no loss in body weight one week following surgery. Functional assessment was performed using a number of reliable behavioural tests: staircase test (fine motor function), horizontal ladder (skilled locomotion), bilateral tactile stimulation test (somatosensory function) and cylinder test (postural weight support). Following ET-1 induced stroke, all tests demonstrated large and sustained sensorimotor deficits in both forelimb and hindlimb function that failed to improve over...Continue Reading

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Citations

Oct 30, 2012·Acta Pharmacologica Sinica·Jessica Mary Livingston-ThomasRichard Andrew Tasker
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May 2, 2013·Stroke; a Journal of Cerebral Circulation·Shanshan ZhaoChuansheng Zhao
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Oct 16, 2021·Journal of Neuroscience Research·Charlotte M ErmineLachlan H Thompson

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