Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation

Pediatric Transplantation
Aksoylar SerapKansoy Savas

Abstract

We present an 18-yr-old adolescent with acute lymphocytic leukemia, who underwent peripheral blood SCT with serologically and histologically documented chronic hepatitis B infection. Prior and during the transplant process, lamivudine was administered orally and he underwent SCT with a twofold decrease in viral load at the time of transplant from his HLA full matched, HBV natural immune (anti-HBs and anti-HBc positive) donor. Successful engraftment was achieved and three months after SCT, HBV seroconversion was documented accompanied with an ALT flare. Chronic graft-versus-host disease coincided after the transplantation, and he has been on immunosuppressive treatment for 25 months with sustained HBV seroconversion. We assume that adoptive immunity transfer combined with antiviral treatment might also constitute sustained seroconversion in chronic HBV, besides the reported risk of reactivation.

References

Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G K LauS K Lam
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Nov 28, 2007·Annual Review of Pathology·Luca G Guidotti, Francis V Chisari
Mar 18, 2008·Blood Reviews·Roberto J Firpi, David R Nelson

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Citations

Apr 24, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C BaleriolaW D Rawlinson

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