Sustained serum 25-hydroxyvitamin D concentrations for one year with cholecalciferol supplementation improves glycaemic control and slows the decline of residual β cell function in children with type 1 diabetes

Pediatric endocrinology, diabetes, and metabolism
Ram Prakash PanjiyarAnil Kumar Bhalla

Abstract

Studies using vitamin D for preservation of residual b-cell function (RBCF) and improvement of glycaemic control in type 1 diabetes (T1D) have shown inconsistent results. The possible causes of the discrepancies in the results are related to the dosage, type, and duration of vitamin D supplementation, C-peptide concentration at entry into the study, and the influence of glycaemic control on RBCF during supplementation. To evaluate the effect of cholecalciferol supplementation on RBCF and glycaemic control in children with T1D. Forty-two children aged 6-12 years and within 1-2 years of diagnosis of T1D received cholecalciferol 3000 IU/day for one year (Group A). Thirty patients were recruited as controls (Group B). The mean changes in stimulated C-peptide levels, HbA1c, fasting blood glucose (FBG), mean blood glucose (MBG), and mean total daily insulin (TDI) dose from baseline to the study endpoint were calculated. Children in Group A showed lower mean FBG, MBG, HbA1c, and lesser TDI as compared to Group B at all follow-up visits. However, the differences in these parameters between the two groups reached statistical significance towards the study endpoint. Within group A, the decline in C-peptide levels from baseline to the end...Continue Reading

Citations

Jun 16, 2019·Medicina·Guido GembilloDomenico Santoro
Sep 26, 2020·Therapeutic Advances in Endocrinology and Metabolism·Liyan LiJunxia Yu
Jun 9, 2020·Minerva pediatrica·Silvia SavastioGianni Bona
Jan 5, 2021·Chinese Medical Journal·Xiao-Bo HuShao-Long Feng

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