PMID: 8611449Apr 1, 1996Paper

Sustained trilineage recovery and disappearance of abnormal chromosome clone in a patient with myelodysplastic syndrome following combination therapy with cytokines (granulocyte colony-stimulating factor and erythropoietin) and high-dose methylprednisolone

British Journal of Haematology
Y ImaiA Takahashi

Abstract

We report a case of hypoplastic myelodyplastic syndrome (MDS) (refractory anemia (RA)) in which sustained trilineage haematological response and persistent disappearance of an abnormal chromosome clone were achieved after treatment with combination therapy of cytokines (granulocyte colony-stimulating factor (G-CSF) and erythropoietin (Epo)) and methylprednisolone (mPSL) pulse dose. The patient's haematological recovery was rapid and maintained even after cessation of the therapy. In addition, the predominant chromosome clone 13q- in bone marrow cells disappeared in the fourth week. The patient's improved bone marrow haemopoiesis and disappearance of the abnormal chromosome has continued to the present, 13 months after treatment. The occurrence of both trilineage response and abnormal chromosome disappearance in MDS patients treated with cytokine(s) or steroids is rare. Combination therapy might therefore be advantageous in MDS.

Citations

Apr 6, 2005·Annals of Hematology·Ashish DixitV P Choudhry
Aug 26, 1998·Leukemia Research·M CetinS Göğüş
Aug 29, 2012·Annals of Neurology·Kurt-Wolfram SühsRicarda Diem
Sep 30, 1998·European Journal of Haematology·A CafollaC S Scott

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