Sustained virological response rates to antiviral therapy in genotype 1 and 3 chronic hepatitis C patients: a study from north India

Journal of Clinical and Experimental Hepatology
Varun GuptaAnil Arora

Abstract

In India, both genotype 3 and 1 are predominant genotypes in patients with chronic hepatitis C (CHC). However, there is scanty data on sustained viral response (SVR) rate with conventionally recommended dual therapy with PEG-IFN and ribavirin. In this retrospective study, consecutive patients of CHC of genotypes 1 and 3, attending the single unit of Gastroenterology of our hospital, who received PEG-IFN and ribavirin therapy, were included. Patients who had co-infection with HIV or HBV were excluded. A total of 114 patients were included in the study median age 44 (15-72) years, 79% males. Most common presentation was with chronic hepatitis, while 10 (9%) patients had compensated cirrhosis. Nine (8%) patients had associated diabetes, 16 (14%) patients gave history of significant alcohol abuse. The median baseline HCV RNA level was 3.0 × 10(5) (1.7 × 10(3)-1.8 × 10(7)) IU/mL. The most common genotype was 3 (75%) followed by genotype 1 (25%). 70% patients received PegIFN-α2a (median dose 180 MIU/wk) and 30% patients received PegIFN-α2b (median dose 80 MIU/wk). The median ribavirin dose was 800 (range 800-1200) mg. SVR in genotype 1 was 64% (18/28) while SVR in genotype 3 was 73% (63/86). The factors predicting SVR on univariate a...Continue Reading

References

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Citations

Mar 6, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vivekanand Jha, Narayan Prasad
Nov 9, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rajiv MehtaVishwa Bhayani
Nov 24, 2017·The Indian Journal of Medical Research·Varun GuptaAnil Arora
Mar 25, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Balkumar Reddy PanyalaNageshwar Reddy Duvvuru

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