Sustaining Blood Lymphocyte Count during Preoperative Chemoradiotherapy as a Predictive Marker for Pathologic Complete Response in Locally Advanced Rectal Cancer

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Jaesung HeoOyeon Cho

Abstract

The objective of this study was to explore the relationship between the circulating lymphocyte level during preoperative chemoradiotherapy (CRT) and pathologic complete response (pCR) in locally advanced rectal cancer. From May 2010 to May 2013, 52 patients treated with preoperative CRT followed by surgery, were analysed. Patients received conventional fractionated radiotherapy (50-54 Gy) with fluorouracil-based chemotherapy. Surgical resection was performed at 4 to 8 weeks after the completion of preoperative CRT. Absolute blood lymphocyte counts and their relative percentage in total white blood cell counts were obtained from complete blood count tests performed prior to and after 4, 8, and 12 weeks of CRT. We analysed the association between achieving pCR and change in blood lymphocyte level during CRT, as well as clinical parameters. Among 52 patients, 14 (26.9%) had evidence of pCR. Sustaining the blood lymphocyte count during CRT (lymphocyte count at 4 weeks/baseline lymphocyte count > 0.35; odds ratio, 8.33; p=0.02) and initial carcinoembryonic antigen < 4.4 ng/mL (odds ratio, 6.71; p=0.03) were significantly associated with pCR in multivariate analyses. Sustaining blood lymphocyte count during preoperative CRT was predi...Continue Reading

References

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Citations

Aug 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Oyeon ChoHyun-Woo Lee
May 1, 2016·World Journal of Surgical Oncology·Katsuji TokuharaMasanori Kon
Jun 19, 2018·Technology in Cancer Research & Treatment·Seung Yeop OhYoung-Taek Oh
Aug 21, 2018·Expert Review of Molecular Diagnostics·Corey TimmermanSergio Huerta
Jul 29, 2016·Anti-cancer Drugs·Sergio Huerta
Jul 6, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Łukasz KuncmanJacek Fijuth
Sep 9, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yingjia WuMian Xi

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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