Sustaining Control of Schistosomiasis Mansoni in Western Côte d'Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration

PLoS Neglected Tropical Diseases
Rufin K AssaréE K N'Goran

Abstract

The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination. In Côte d'Ivoire, a 5-year cluster-randomized trial is being implemented in 75 schools to sustain the control of schistosomiasis mansoni. We report Schistosoma mansoni infection levels in children one year after the initial school-based treatment (SBT) with praziquantel and compare with baseline results to determine the effect of the intervention. The baseline cross-sectional survey was conducted in late 2011/early 2012 and the first follow-up in May 2013. Three consecutive stool samples were collected from 9- to 12-year-old children in 75 schools at baseline and 50 schools at follow-up. Stool samples were subjected to duplicate Kato-Katz thick smears. Directly observed treatment (DOT) coverage of the SBT was assessed and the prevalence and intensity of S. mansoni infection compared between baseline and follow-up. The S. mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5-24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at ...Continue Reading

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Citations

Sep 12, 2019·The Cochrane Database of Systematic Reviews·David C Taylor-RobinsonPaul Garner
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Sue BinderDaniel G Colley
Jul 4, 2020·Parasites & Vectors·Rufin K AssaréJürg Utzinger
Jun 11, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Philip T LoVerdeStanton F McHardy
Aug 21, 2021·PLoS Neglected Tropical Diseases·Jeffrey GlennKatherine Williams

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