Sustentacular cells occur frequently in the familial form of medullary thyroid carcinoma

The Journal of Pathology
Xavier Matias-GuiuJ Prat

Abstract

The presence and distribution of S-100-immunoreactive sustentacular cells were investigated by immunohistochemistry in 67 medullary thyroid carcinomas (MTCs). The familial or sporadic status of the tumours was assessed by clinical data and confirmed by the identification of RET germline mutations using the polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and restriction analysis. Sustentacular cells were detected in 19 tumours (28.3 per cent). They were found significantly more frequently in the familial (15/24, 62.5 per cent) than in the sporadic MTCs (4/43, 9.3 per cent). The results indicate that sustentacular cells are commonly found in familial MTC and their presence in any MTC may be regarded as an indirect indicator that the tumour might be of the familial type.

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Citations

Jan 13, 2006·Thyroid : Official Journal of the American Thyroid Association·Maximilian BockhornChristoph E Broelsch
Oct 23, 2013·Seminars in Diagnostic Pathology·Thomas G PapathomasArthur S Tischler
Jul 18, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·A RyskaA Kohout
Nov 7, 1999·The American Journal of Pathology·X Matias-Guiu
Jun 21, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Michael J MurphyJane M Grant-Kels
Apr 29, 2015·Der Pathologe·S SynorackiK W Schmid
Mar 4, 2020·Diagnostic Cytopathology·Yanjun HouDeborah J Chute
Dec 18, 2013·Endocrine Pathology·Xavier Matias-Guiu, Ronald De Lellis

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