Suvorexant for the Treatment of Insomnia in Adolescents

Journal of Child and Adolescent Psychopharmacology
Kentaro KawabeYasunori Oka

Abstract

Suvorexant is the first dual orexin receptor antagonist for treating insomnia. This study aimed to evaluate the tolerability, efficacy, and safety of suvorexant on insomnia in adolescents. Thirty patients (8 male and 22 female; mean standard deviation age: 15.7 ± 2.4 years; range: 10-20) with insomnia were administered suvorexant. Clinical background, persistence rate, the Clinical Global Impression (CGI), and the Athens Insomnia Scale (AIS) were compared between patients who continued and discontinued suvorexant treatment. Seventeen patients (56.7%) successfully continued taking suvorexant. Among the 13 patients who did not continue treatment, 5 patients were lost to follow-up. Of the remaining eight who did not continue treatment, four decided to discontinue of their own accord, two decided to discontinue due to lack of effectiveness, and two decided to discontinue due to adverse reaction, namely abnormal dreams. Among patients who completed the study, CGI significantly decreased from 3.6 ± 0.8 to 3.1 ± 0.9 (p = 0.014). The score of sleep quality in AIS was significantly higher among the patients who discontinued suvorexant than those who continued suvorexant (p = 0.02). Our results indicate that suvorexant could be considere...Continue Reading

References

Aug 23, 2003·Journal of Psychosomatic Research·Constantin R SoldatosThomas J Paparrigopoulos
Jul 17, 2010·Annals of the New York Academy of Sciences·Takeshi SakuraiNatsuko Tsujino
May 24, 2011·Pediatric Clinics of North America·Judith A Owens, Jodi A Mindell
Jul 21, 2012·Progress in Brain Research·Anthony L GotterJohn J Renger
Apr 25, 2013·Journal of Sleep Research·Mari HysingBørge Sivertsen
Aug 6, 2013·Psychiatry and Clinical Neurosciences·Isa OkajimaYuichi Inoue
Dec 21, 2014·Biological Psychiatry·W Joseph HerringDavid Michelson

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Citations

Apr 30, 2019·Journal of Child and Adolescent Psychopharmacology·Diana I PrietoDaniel F Connor
Sep 3, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Shigemi KimuraYutaka Takaoka
Oct 23, 2019·Expert Opinion on Pharmacotherapy·Oliviero BruniRaffaele Ferri
Sep 12, 2018·Medical Sciences : Open Access Journal·Innessa Donskoy, Darius Loghmanee
Aug 7, 2020·Continuum : Lifelong Learning in Neurology·Amy Licis
May 4, 2021·Drug and Alcohol Dependence·Natalie E ZlebnikMarilyn E Carroll
Oct 7, 2021·European Child & Adolescent Psychiatry·Aaron D Besterman, Shafali S Jeste

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